Multifunctional microsphere dressings via metal ligand bonding engineering for infectious wound healing

IF 14.3 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Zhongyi Sun, Ningning Cheng, Zhuyun Cai, Zhengran Ying, Haibo Liu, Ziyan Chen, Hua Zeng, Mengting Yin, Haijiang Liu, Shuo Tan, Xuhui Zhou, Xinyu Zhao, Feng Chen
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Abstract

Surgical incision infection is the most common postoperative complication that poses a serious threat to human health. In this work, the iron gallate (GA-Fe) modified hyaluronic acid microspheres (GFe@HAMSs) multifunctional dressings with antibacterial activity, biodegradability, and the ability to promote tissue regeneration for infectious wound healing are prepared via the bonding engineering between bioactive iron ions and ligands from both polyphenol (i.e. gallic acid, GA) and HAMSs matrix. In our strategy, the Fe-HAMS interaction is first constructed, leading to the shrinkage of iron-doped HAMSs (Fe@HAMSs). Then, the addition of GA further tunes the metal-matrix bonding by introducing the competitive equilibrium between Fe-HAMS and Fe-GA chelation, leading to the volume expansion of GFe@HAMSs. The introduction of iron ions can effectively shorten the inflammatory response and reverse the iron-deficient microenvironment, thereby transforming the wound microenvironment into one conducive to tissue regeneration. Benefitting from these bioactive effects of iron ions and the photothermal antibacterial activity of GA-Fe, the GFe@HAMSs significantly accelerate the wound healing process for rat skin-infected wounds by inhibiting the inflammatory response and macrophage polarization and promoting angiogenesis and tissue remodeling. The GFe@HAMSs proposed in this work not only provide a biomaterial for infectious wound healing but also offer a new strategy for designing multifunctional dressing.

Abstract Image

通过金属配体键合工程实现多功能微球敷料,促进感染性伤口愈合
手术切口感染是最常见的术后并发症,严重威胁人类健康。在这项工作中,通过生物活性铁离子与多酚(即没食子酸)配体和 HAMSs 基质之间的键合工程,制备了具有抗菌活性、生物降解性和促进组织再生能力的没食子酸铁(GA-Fe)修饰透明质酸微球(GFe@HAMSs)多功能敷料,用于感染性伤口的愈合。在我们的策略中,首先构建铁-HAMS相互作用,导致掺铁 HAMSs(Fe@HAMSs)收缩。然后,GA 的加入通过引入 Fe-HAMS 和 Fe-GA 螯合之间的竞争性平衡,进一步调整了金属-基质键合,从而导致 GFe@HAMS 的体积膨胀。铁离子的引入可有效缩短炎症反应,扭转缺铁的微环境,从而将伤口微环境转变为有利于组织再生的环境。得益于铁离子的这些生物活性作用和 GA-Fe 的光热抗菌活性,GFe@HAMS 通过抑制炎症反应和巨噬细胞极化,促进血管生成和组织重塑,显著加快了大鼠皮肤感染伤口的愈合过程。本研究提出的 GFe@HAMS 不仅为感染性伤口愈合提供了一种生物材料,还为设计多功能敷料提供了一种新策略。
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来源期刊
Journal of Materials Science & Technology
Journal of Materials Science & Technology 工程技术-材料科学:综合
CiteScore
20.00
自引率
11.00%
发文量
995
审稿时长
13 days
期刊介绍: Journal of Materials Science & Technology strives to promote global collaboration in the field of materials science and technology. It primarily publishes original research papers, invited review articles, letters, research notes, and summaries of scientific achievements. The journal covers a wide range of materials science and technology topics, including metallic materials, inorganic nonmetallic materials, and composite materials.
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