Biochemical processes mediating neurotoxicity induced by synthetic food dyes: A review of current evidence

IF 8.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Chemosphere Pub Date : 2024-09-12 DOI:10.1016/j.chemosphere.2024.143295

Kesavan Damotharan, Gokul Sudhakaran, Meenakshi Ramu, Mohana Krishnan, Karthick Raja Namasivayam S, Jesu Arockiaraj

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Abstract

The extensive use of synthetic food dyes in the food industry, primarily due to their durability and cost-effectiveness compared to natural colorants, has raised significant health concerns. Of particular concern are the potential neurotoxic effects of six commonly used synthetic food dyes: Tartrazine (E102/FD&C Yellow No. 5), Erythrosine (E127/FD&C Red No. 3), Brilliant Blue FCF (E133/FD&C Blue No. 1), Allura Red AC (E129/FD&C Red No. 40), Sunset Yellow FCF (E110/FD&C Yellow No. 6), and Indigo Carmine (E132/FD&C Blue No. 2). This review delves into the metabolic pathways and neurotoxicity mechanisms of each dye, highlighting their effects on oxidative stress, neurotransmitter imbalances, mitochondrial dysfunction, and inflammatory responses. The evidence suggests that these dyes can significantly impact brain function and overall neurological health. This review underscores the importance of continued research in this field, as it is crucial to fully comprehend the neurotoxic processes of synthetic food dyes and to inform regulatory decisions that are crucial for safeguarding public health.

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合成食品染料诱发神经毒性的生化过程：现有证据综述

与天然着色剂相比，合成食品染料的耐久性和成本效益是食品工业广泛使用合成食品染料的主要原因。六种常用合成食品染料的潜在神经毒性效应尤其令人担忧：塔特嗪（E102/FD&C 黄 5 号）、赤藓红（E127/FD&C 红 3 号）、艳蓝 FCF（E133/FD&C 蓝 1 号）、Allura 红 AC（E129/FD&C 红 40 号）、日落黄 FCF（E110/FD&C 黄 6 号）和靛蓝卡明（E132/FD&C 蓝 2 号）。本综述深入探讨了每种染料的代谢途径和神经毒性机制，重点介绍了它们对氧化应激、神经递质失衡、线粒体功能障碍和炎症反应的影响。证据表明，这些染料会严重影响大脑功能和整体神经系统健康。本综述强调了在这一领域继续开展研究的重要性，因为这对于全面了解合成食品染料的神经毒性过程以及为监管决策提供信息至关重要，而监管决策对于保障公众健康至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemosphere 环境科学-环境科学

CiteScore

15.80

自引率

8.00%

发文量

4975

审稿时长

3.4 months

期刊介绍： Chemosphere, being an international multidisciplinary journal, is dedicated to publishing original communications and review articles on chemicals in the environment. The scope covers a wide range of topics, including the identification, quantification, behavior, fate, toxicology, treatment, and remediation of chemicals in the bio-, hydro-, litho-, and atmosphere, ensuring the broad dissemination of research in this field.

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