Effects of Cryolipolysis on the Conversion of White Adipose Tissue: Pilot Study

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2024-09-10 DOI:10.1002/lsm.23839

Christiane Rodrigues Tofoli Palauro, Patrícia Froes Meyer, Ciro Dantas Soares, Eneida de Morais Carreiro, Flávio de Paiva Dumaresq, Fernando Cesar Camara de Oliveira, Ana Laura Martins de Andrade, Priscila da S. P. S. Daumas

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引用次数: 0

Abstract

IntroductionCryolipolysis (CLL) is a widely employed noninvasive procedure for body fat reduction. It operates by inducing cooling, leading to the crystallization of cytoplasmic lipids, loss of cellular integrity, and apoptosis/necrosis of adipocytes, accompanied by local inflammation. Ongoing discussions revolve around CLL's potential to transform white adipocytes into brown adipocytes, potentially yielding more significant effects compared to alternative procedures.ObjectiveThus, this randomized, blinded clinical study aimed to investigate the effects of CLL on adipose tissue and elucidate the mechanisms involved in its application and capacity for adipocyte conversion.MethodologyTissue samples from six patients were assessed at intervals of 45, 60, and 90 days following the application of the CLL protocol during abdominoplasty surgeries.ResultsThe samples underwent immunohistochemical analyses targeting various markers, revealing higher expression of PPAR‐gamma, PPAR‐alpha, and UCP‐1 markers in CLL‐treated samples.ConclusionTherefore, the present study suggests that CLL has the ability to intervene in adipocyte conversion.

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冷冻溶脂对白色脂肪组织转化的影响：试点研究

导言冷冻溶脂（CLL）是一种广泛采用的非侵入性减脂方法。其原理是通过冷却，使细胞质脂质结晶、细胞完整性丧失、脂肪细胞凋亡/坏死，并伴有局部炎症。因此，这项随机、盲法临床研究旨在调查 CLL 对脂肪组织的影响，并阐明其应用机制和脂肪细胞转化能力。方法在腹部整形手术中应用 CLL 方案后，分别在 45 天、60 天和 90 天对六名患者的组织样本进行评估。结果对样本进行了针对各种标记物的免疫组化分析，结果显示在 CLL 处理的样本中 PPAR-γ、PPAR-α 和 UCP-1 标记物的表达较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.