Recent Applications of Amphiphilic Copolymers in Drug Release Systems for Skin Treatment

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmaceutics Pub Date : 2024-09-13 DOI:10.3390/pharmaceutics16091203

Yudy Vanessa Cardona, Lizeth Geraldine Muñoz, Daniela Gutierrez Cardozo, Andrés Felipe Chamorro

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引用次数: 0

Abstract

Amphiphilic copolymers (ACs) are versatile systems with self-assembling and aggregating properties, enabling the formation of nanomaterials (NMs) such as micelles, vesicles, nanocapsules, and nanogels. These materials have been extensively explored for the delivery of various drugs and active compounds, enhancing the solubility and permeation of poorly water-soluble drugs into skin tissue. This improvement facilitates the treatment of skin diseases, including chronic conditions like cancer, as well as infections caused by bacteria, fungi, and viruses. This review summarizes recent applications of ACs in skin treatment, with a particular focus on their use in anti-cancer drug therapy. It covers the synthesis, classification, and characterization of ACs using various experimental techniques. Additionally, it discusses recent research on different drug delivery pathways using ACs, including encapsulation efficiency, release behavior, characteristics, applications, and responses to various chemical and physical stimuli (both in vivo and in vitro). Furthermore, this review provides a comprehensive analysis of the effects of ACs NMs on several skin diseases, highlighting their potential as alternative treatments.

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两亲共聚物在皮肤治疗药物释放系统中的最新应用

两性共聚物（AC）是一种多功能体系，具有自组装和聚集特性，可形成胶束、囊泡、纳米胶囊和纳米凝胶等纳米材料（NM）。这些材料已被广泛用于输送各种药物和活性化合物，提高水溶性差的药物在皮肤组织中的溶解度和渗透性。这种改善有助于治疗皮肤疾病，包括癌症等慢性疾病，以及细菌、真菌和病毒引起的感染。本综述总结了 ACs 在皮肤治疗中的最新应用，尤其关注其在抗癌药物治疗中的应用。内容包括 ACs 的合成、分类以及利用各种实验技术对其进行表征。此外，它还讨论了使用 ACs 的不同给药途径的最新研究，包括封装效率、释放行为、特性、应用以及对各种化学和物理刺激（体内和体外）的反应。此外，这篇综述还全面分析了 ACs NMs 对几种皮肤病的影响，强调了它们作为替代治疗方法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.90

自引率

11.10%

发文量

2379

审稿时长

16.41 days

期刊介绍： Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications, and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.