Characterizing Midlife-Onset Alcohol Dependence: Implications for Etiology, Prevention, and Healthy Aging

IF 4.8 2区医学 Q1 PSYCHIATRY

Clinical Psychological Science Pub Date : 2024-08-24 DOI:10.1177/21677026241260249

Lara Khalifeh, Avshalom Caspi, Kallisse R. Dent, HonaLee Harrington, Madeline H. Meier, Richie Poulton, Sandhya Ramrakha, Terrie E. Moffitt, Leah S. Richmond-Rakerd

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引用次数: 0

Abstract

We evaluated the developmental epidemiology of midlife-onset alcohol dependence (AD) in the Dunedin Study ( N = 1,037), a population-representative cohort followed across 5 decades. At ages 18, 21, 26, 32, 38, and 45, past-year AD prevalence was 11.0%, 18.4%, 13.6%, 8.1%, 9.6%, and 11.3%, respectively. As expected, relative to never-diagnosed individuals, individuals with early onset AD (first diagnosis at age 18 or age 21, prevalence = 22.9%) were distinguished by a range of early life and adult correlates. Individuals with midlife-onset AD (first diagnosis at age 38 or age 45, prevalence = 5.6%) were distinguished by fewer early life correlates, but exhibited a family history of AD and adolescent dysregulation and marijuana use. They were characterized by an array of adult correlates, including internalizing disorders, mental-health-treatment contact, criminal behavior, perceived stress, coping by drinking, lower likelihood of marriage and parenthood, and reduced preparedness for old age. They also experienced more adult alcohol-related impairment than the early onset group. Results can guide efforts to reduce midlife alcohol-related problems and support healthy aging.

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中年酒精依赖症的特征：对病因学、预防和健康老龄化的影响

我们在达尼丁研究（Dunedin Study，N = 1,037）中评估了中年酒精依赖（AD）的发展流行病学。在 18 岁、21 岁、26 岁、32 岁、38 岁和 45 岁时，过去一年的酒精依赖症发病率分别为 11.0%、18.4%、13.6%、8.1%、9.6% 和 11.3%。正如预期的那样，与从未诊断过的人相比，早发性注意力缺失症患者（首次诊断年龄为18岁或21岁，患病率=22.9%）在早期生活和成年后的一系列相关因素中脱颖而出。中年发病的注意力缺失症患者（首次确诊年龄为38岁或45岁，患病率=5.6%）的早期生活相关因素较少，但他们有注意力缺失症家族史、青春期行为失调和吸食大麻。他们具有一系列成年相关因素，包括内化障碍、接触心理健康治疗、犯罪行为、感知压力、通过饮酒来应对、结婚和为人父母的可能性较低以及对老年生活的准备不足。与早发组相比，他们在成年后也经历了更多与酒精相关的损害。研究结果可为减少中年酒精相关问题和支持健康老龄化提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychological Science Psychology-Clinical Psychology

CiteScore

9.70

自引率

2.10%

发文量

期刊介绍： The Association for Psychological Science’s journal, Clinical Psychological Science, emerges from this confluence to provide readers with the best, most innovative research in clinical psychological science, giving researchers of all stripes a home for their work and a place in which to communicate with a broad audience of both clinical and other scientists.