A Bayesian Longitudinal Network Analysis of Panic-Disorder Symptoms and Respiratory Biomarkers

IF 4.8 2区医学 Q1 PSYCHIATRY

Clinical Psychological Science Pub Date : 2024-08-26 DOI:10.1177/21677026241263330

Galen P. Cassidy, Mikael Rubin, Santiago Papini, Michael J. Telch

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引用次数: 0

Abstract

The network theory of psychopathology is gaining popularity as a conceptualization of psychological disorders that may aid the identification of mechanisms of therapeutic change. However, many existing networks do not consider other relevant variables beyond the symptoms themselves. We present a large-scale ( n = 1,873), longitudinal Bayesian network analysis of panic disorder using the symptom items from the Panic Disorder Severity Scale (PDSS) and two respiratory biomarkers (respiration rate and end-tidal CO2) collected during routine monitoring of a capnometry-guided respiratory intervention (CGRI). Our findings offer support for avoidance and fear of panic as drivers of subsequent panic-disorder symptoms over the 4-week course of treatment. Moreover, respiration rate but not end-tidal CO2 was associated with downstream PDSS symptoms. These findings provide further evidence supporting the role of respiratory biomarkers in the maintenance of panic disorder and some support for normalization of dysfunctional breathing as one therapeutic mechanism governing CGRI.

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恐慌症症状与呼吸系统生物标志物的贝叶斯纵向网络分析

精神病理学网络理论作为一种心理障碍的概念化理论，正日益受到人们的欢迎，它可以帮助确定治疗改变的机制。然而，许多现有的网络并没有考虑症状本身之外的其他相关变量。我们利用恐慌症严重程度量表（PDSS）中的症状项目以及在对帽式呼吸引导的呼吸干预（CGRI）进行常规监测时收集的两个呼吸生物标志物（呼吸频率和潮气末二氧化碳），对恐慌症进行了大规模（n = 1,873）、纵向贝叶斯网络分析。我们的研究结果表明，在为期 4 周的治疗过程中，回避和对恐慌的恐惧是随后出现恐慌症症状的驱动因素。此外，呼吸频率（而非潮气末二氧化碳）与下游 PDSS 症状相关。这些研究结果进一步证明了呼吸生物标志物在维持惊恐障碍中的作用，并在一定程度上支持将呼吸功能障碍恢复正常作为 CGRI 的一种治疗机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychological Science Psychology-Clinical Psychology

CiteScore

9.70

自引率

2.10%

发文量

期刊介绍： The Association for Psychological Science’s journal, Clinical Psychological Science, emerges from this confluence to provide readers with the best, most innovative research in clinical psychological science, giving researchers of all stripes a home for their work and a place in which to communicate with a broad audience of both clinical and other scientists.