Resin Acid Copper Salt, an Interesting Chemical Pesticide, Controls Rice Bacterial Leaf Blight by Regulating Bacterial Biofilm, Motility, and Extracellular Enzymes

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2024-09-11 DOI:10.3390/molecules29184297

Lihong Shi, Xiang Zhou, Puying Qi

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引用次数: 0

Abstract

Bacterial virulence plays an important role in infection. Antibacterial virulence factors are effective for preventing crop bacterial diseases. Resin acid copper salt as an effective inhibitor exhibited excellent anti-Xanthomonas oryzae pv. oryzae (Xoo) activity with an EC50 of 50.0 μg mL−1. Resin acid copper salt (RACS) can reduce extracellular polysaccharides’ (EPS’s) biosynthesis by down-regulating gumB relative expression. RACS can also effectively inhibit the bio-mass of Xoo biofilm. It can reduce the activity of Xoo extracellular amylase at a concentration of 100 μg mL−1. Meanwhile, the results of virtual computing suggested that RACS is an enzyme inhibitor. RACS displayed good curative activity with a control effect of 38.5%. Furthermore, the result of the phytotoxicity assessment revealed that RACS exhibited slight toxicity compared with the control at a concentration of 200 μg mL−1. The curative effect was increased to 45.0% using an additional antimicrobial agent like orange peel essential oil. RACS markedly inhibited bacterial pathogenicity at a concentration of 100 μg mL−1 in vivo.

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树脂酸铜盐是一种有趣的化学农药，它通过调节细菌的生物膜、运动性和胞外酶来控制水稻细菌性叶枯病

细菌毒力在感染中起着重要作用。抗菌毒力因子可有效预防作物细菌病害。树脂酸铜盐作为一种有效的抑制剂，具有极佳的抗黄单胞杆菌（Xoo）活性，EC50 为 50.0 μg mL-1。树脂酸铜盐（RACS）可通过下调 gumB 的相对表达来减少胞外多糖（EPS）的生物合成。RACS 还能有效抑制 Xoo 生物膜的生物量。在浓度为 100 μg mL-1 时，它能降低 Xoo 细胞外淀粉酶的活性。同时，虚拟计算的结果表明，RACS 是一种酶抑制剂。RACS 显示出良好的治疗活性，控制效果为 38.5%。此外，植物毒性评估结果表明，与对照组相比，浓度为 200 μg mL-1 的 RACS 具有轻微毒性。使用橙皮精油等额外的抗菌剂后，治疗效果提高到 45.0%。浓度为 100 μg mL-1 的 RACS 能明显抑制细菌在体内的致病性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.