Biosensor Performance Signature Enhancement with Silver-MXene-Graphene for Brain Tumor Diagnosis Through the Employment of Surface Plasmon Resonance

IF 3.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2024-08-14 DOI:10.1007/s11468-024-02483-2

Anurag Upadhyay, Shivam Singh, Bhargavi Chaudhary, Rajeev Kumar, Prem P. Singh, M. G. Daher, Priyanka Bhardwaj, Mahmoud M. A. Eid, Ahmed Nabih Zaki Rashed

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Abstract

In this work, we present a surface plasmon resonance (SPR) based photonic biosensor for the detection and differentiation of healthy and infected brain tissues, including lesions, tumors, and malignant tissues. The biosensor design incorporates a BK-7 prism, silver (Ag), MXene (Ti₃C₂T_x), and graphene. Silver serves as the plasmonic material, coated on the prism’s flat surface to enhance plasmon generation, assisted by MXene and graphene for improved sensing performance. Extensive analysis and investigation have been conducted to leverage the unique characteristics of graphene and MXene in the design of this highly sensitive biosensor. The biosensor’s performance has been evaluated in terms of sensitivity, with remarkable results. The proposed biosensor demonstrates an exceptionally high sensitivity (S) of 240 \(^\circ\)/RIU, detection accuracy of 0.1984 \(^\circ\), and figure of merit (FoM) of 47.81/RIU. These findings confirm the biosensor’s reliability and effectiveness in accurately identifying various brain tumor tissues.

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利用表面等离子体共振增强银-MXene-石墨烯的生物传感器性能特征，用于脑肿瘤诊断

在这项工作中，我们提出了一种基于表面等离子体共振（SPR）的光子生物传感器，用于检测和区分健康和受感染的脑组织，包括病变、肿瘤和恶性组织。该生物传感器设计采用了 BK-7 棱镜、银（Ag）、MXene（Ti3C2Tx）和石墨烯。银作为等离子体材料，镀在棱镜的平面上以增强等离子体的产生，MXene 和石墨烯的辅助则提高了传感性能。为了利用石墨烯和 MXene 的独特特性来设计这种高灵敏度的生物传感器，我们进行了大量的分析和研究。在灵敏度方面对该生物传感器的性能进行了评估，结果令人瞩目。该生物传感器的灵敏度（S）高达 240 \（^\circ\）/RIU，检测精度为 0.1984 \（^\circ\），优点系数（FoM）为 47.81/RIU。这些发现证实了生物传感器在准确识别各种脑肿瘤组织方面的可靠性和有效性。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.