Grating Coupled Self-referenced SPP Biosensor for Detection of Glucose Level in Urine in Optical Communication Band

IF 3.3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL
Lopamudra Sen, Bratati Mukhopadhyay
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Abstract

The expeditious growth and development of different optical-based medical and biomedical instruments to detect various diseases nowadays put itself a potential research topic. In recent times, prevalence of diabetes mellitus among people has become alarming and often life-threatening. In this regard, efficient sensors with high sensitivity are extremely necessary for monitoring and quantification of glucose level in the urine samples. A self-referenced surface plasmon polariton sensor using trapezoidal TiO2 grating on thin Au film has been proposed here to detect glucose level in urine samples for the first time. The proposed sensor has been optimized for better sensitivity and can be operated in the optical communication band which can help to achieve existing mature light sources and light detection instruments. The sensor has been designed with a thin dielectric grating on top of thin metal film resulting in generation of two surface plasmons at the two boundaries of the metal film. This technique is fascinating to improve the accuracy of sensitivity of the device and helps to eliminate cross-sensitivity problem. As a result, this type of self-referenced biosensor can be used for a wide range of applications in fields such as biochemistry, biophysics, and environmental monitoring. The proposed sensor shows a higher sensitivity compared to that of other plasmonic sensors reported in recent times due to incorporation of trapezoidal-shaped grating structure for the first time instead of rectangular shape. The spectral sensitivity of the proposed structure was obtained as 666.67 nm/RIU with optimized values of different structural parameters.

Abstract Image

用于在光通信波段检测尿液中葡萄糖含量的光栅耦合自参考 SPP 生物传感器
如今,用于检测各种疾病的各种光学医疗和生物医学仪器发展迅速,成为一个潜在的研究课题。近来,糖尿病在人群中的发病率令人担忧,而且常常危及生命。因此,高灵敏度的高效传感器对于监测和量化尿液样本中的葡萄糖含量极为必要。本文首次提出了一种在金薄膜上使用梯形二氧化钛光栅的自参考表面等离子体极化子传感器,用于检测尿液样本中的葡萄糖含量。该传感器经过优化,灵敏度更高,可在光通信波段工作,有助于实现现有的成熟光源和光检测仪器。该传感器在金属薄膜上设计了一个薄介质光栅,从而在金属薄膜的两个边界产生了两个表面等离子体。这种技术可以提高设备灵敏度的准确性,并有助于消除交叉灵敏度问题。因此,这种自参照生物传感器可广泛应用于生物化学、生物物理学和环境监测等领域。由于首次采用了梯形光栅结构而非矩形结构,与近期报道的其他等离子传感器相比,所提出的传感器具有更高的灵敏度。在对不同结构参数进行优化后,拟议结构的光谱灵敏度为 666.67 nm/RIU。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Plasmonics
Plasmonics 工程技术-材料科学:综合
CiteScore
5.90
自引率
6.70%
发文量
164
审稿时长
2.1 months
期刊介绍: Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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