Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2024-09-11 DOI:10.1007/s40520-024-02843-2

Zuying Liu, Jiaming Fan, Huilian Bu, Lijun Fu, Cong Li, Letian Ma, Cunlong Kong, Zhongyuan Lu, Xinxin Li, Jian Wang, Qingying Liu, Jingjing Yuan, Xiaochong Fan

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Abstract

Background

Previous observational studies have revealed a potentially robust bidirectional relationship between frailty and low back pain (LBP). However, the precise causal relationship remains unclear.

Methods

To examine the potential causal association between frailty and LBP, we conducted bidirectional two-sample Mendelian randomization analysis (MR) study. Genetic data on frailty index (FI) and LBP were acquired from publicly available genome-wide association studies (GWAS). Various MR methodologies were utilized, such as inverse variance weighting (IVW), weighted median, and MR-Egger, to evaluate causality. Additionally, sensitivity analyses were conducted to evaluate the robustness of the findings.

Results

Genetically predicted higher FI (IVW, odds ratio [OR] = 1.66, 95% CI 1.17–2.36, p = 4.92E-03) was associated with a higher risk of LBP. As for the reverse direction, genetic liability to LBP showed consistent associations with a higher FI (IVW, OR = 1.13, 95% CI 1.07–1.19, p = 2.67E-05). The outcomes from various MR techniques and sensitivity analyses indicate the robustness of our findings.

Conclusion

Our research findings provide additional evidence bolstering the bidirectional causal relationship between frailty and LBP.

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虚弱与腰背痛之间的因果关系：双向双样本泯灭随机研究

背景以往的观察性研究显示，虚弱与腰背痛之间存在潜在的密切双向关系。为了研究虚弱与腰背痛之间的潜在因果关系，我们进行了双向双样本孟德尔随机分析（MR）研究。有关虚弱指数（FI）和枸杞多糖的遗传数据来自公开的全基因组关联研究（GWAS）。研究采用了各种 MR 方法，如反方差加权（IVW）、加权中位数和 MR-Egger，以评估因果关系。结果遗传预测的较高 FI（IVW，比值比 [OR] = 1.66，95% CI 1.17-2.36，p = 4.92E-03）与较高的枸杞痛风险相关。至于反方向，枸杞痛的遗传易感性与较高的 FI 有一致的关联（IVW，OR = 1.13，95% CI 1.07-1.19，p = 2.67E-05）。各种磁共振技术和敏感性分析的结果表明了我们研究结果的稳健性。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.