A DOUBLE‐BLIND STUDY OF THE VALUE OF TREATMENT WITH A SINGLE DOSE TINIDAZOLE OF PARTNERS TO FEMALES WITH TRICHOMONIASIS

IF 3.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Acta Obstetricia et Gynecologica Scandinavica Pub Date : 2024-09-12 DOI:10.1111/j.1600-0412.1981.tb00037.x

Jens Lyng, Jan Christensen

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Abstract

Tinidazole 2 g single oral dose was given to 137 females with positive trichomonal cultures. On a random basis the same dose of tinidazole was given to half the sexual partners, and matching placebo to the other half. One to two weeks after treatment 5 females had positive cultures, indicating a primary cure rate of 96.4%. At an average of 2 months after treatment and 6 weeks after resuming sexual activity, 118 females were reexamined; 17 had a positive culture, giving an overall relapse rate of 14.4%. The relapse rate with tinidazole‐treated partner was 5.1%, and with placebo‐treated partner 23.7% (p = 0.01). The definitive cure rate after a single dose of tinidazole 2 g was in females with treated partner 91.8% and with untreated partner 72.6%. It is concluded that a single dose of tinidazole is an effective treatment for females with trichomoniasis but to avoid relapse it is necessary to treat the sexual partner too, cond follow‐up, also with trichomonal culture. At this time they were questioned concerning their sexual activity: the date of first intercourse after treatment and the frequency of intercourse.

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滴虫病女性患者伴侣单剂量替硝唑治疗价值的双盲研究

对 137 名滴虫培养呈阳性的女性口服 2 克替硝唑。随机给一半的性伴侣服用相同剂量的替硝唑，给另一半性伴侣服用相同剂量的安慰剂。治疗一至两周后，5 名女性的培养结果呈阳性，表明初步治愈率为 96.4%。在治疗后平均 2 个月和恢复性生活 6 周后，对 118 名女性进行了复查，其中 17 人的培养呈阳性，总复发率为 14.4%。接受替硝唑治疗的伴侣的复发率为 5.1%，接受安慰剂治疗的伴侣的复发率为 23.7%（P = 0.01）。单剂量 2 克替硝唑治疗后，女性患者的最终治愈率为 91.8%，未治疗的患者为 72.6%。结论是，单剂量替硝唑是治疗女性滴虫病的有效方法，但为了避免复发，有必要对性伴侣也进行治疗，并进行滴虫培养。在此期间，她们被询问了性活动情况：治疗后首次性交的日期和性交频率。

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来源期刊

Acta Obstetricia et Gynecologica Scandinavica 医学-妇产科学

CiteScore

8.00

自引率

4.70%

发文量

180

审稿时长

3-6 weeks

期刊介绍： Published monthly, Acta Obstetricia et Gynecologica Scandinavica is an international journal dedicated to providing the very latest information on the results of both clinical, basic and translational research work related to all aspects of women’s health from around the globe. The journal regularly publishes commentaries, reviews, and original articles on a wide variety of topics including: gynecology, pregnancy, birth, female urology, gynecologic oncology, fertility and reproductive biology.