Associations between exposure to OPEs and rheumatoid arthritis risk among adults in NHANES, 2011-2018

Sneha Singh, Elsa Pirouz, Amir Shahmoradi
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Abstract

Rheumatoid arthritis (RA) has an intricate etiology that includes environmental factors as well as genetics. Organophosphate esters (OPEs) are frequently used as chemical additives in many personal care products and household items. However, there has been limited research on their potential effects on rheumatoid arthritis (RA). The specific associations between OPEs and RA remain largely unexplored. This study investigates any potential associations between adult rheumatoid arthritis risk and exposure to OPEs. We investigated data from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 among participants over 20 years old. In two models, multivariable logistic regression was utilized to investigate the relationship between exposure to OPEs and RA. Furthermore, subgroup analyses stratified by age, gender, and dose exposure response were evaluated. Generalized additive models and smooth curve fits were used to characterize the nonlinear relationship between RA and OPEs. In conclusion, 5490 individuals (RA: 319, Non-RA: 5171) were analyzed. Higher quantiles (Q4) of DPHP and DBUP showed a higher prevalence of RA than the lowest quantiles. Our findings show that adult RA prevalence is higher in those who have been exposed to OPEs (DPHP, DBUP). Interestingly, these correlations seem to be stronger among women, the elderly, those with higher BMIs, and those who have diabetes. The dose-response curve for DPHP and DBUP demonstrated an upward-sloping trend. In contrast, BCEP and BCPP showed a U-shaped relationship and an inverted U-shaped relationship with the probability of RA.BDCPP demonstrated a complex relationship with a peak at lower concentrations followed by a decrease. Finally, our study also concludes that exposure to OPEs plays a crucial role in the pathogenesis of RA.
2011-2018年NHANES调查中成年人暴露于OPE与类风湿性关节炎风险之间的关系
类风湿性关节炎(RA)的病因错综复杂,包括环境因素和遗传因素。有机磷酸酯(OPE)经常被用作许多个人护理产品和家居用品的化学添加剂。然而,有关它们对类风湿性关节炎(RA)潜在影响的研究却很有限。OPE 与类风湿关节炎之间的具体关联在很大程度上仍未得到探讨。本研究调查了成人类风湿性关节炎风险与暴露于 OPE 之间的任何潜在关联。我们调查了 2011-2018 年美国国家健康与营养调查(NHANES)中 20 岁以上参与者的数据。在两个模型中,我们利用多变量逻辑回归来研究暴露于OPE与RA之间的关系。此外,还评估了按年龄、性别和剂量暴露反应分层的亚组分析。使用广义加法模型和平滑曲线拟合来描述 RA 与 OPE 之间的非线性关系。最后,对 5490 人(RA:319 人,非 RA:5171 人)进行了分析。DPHP和DBUP的较高量值(Q4)比最低量值显示出更高的RA患病率。我们的研究结果表明,接触过 OPEs(DPHP、DBUP)的人群中,成人 RA 患病率较高。有趣的是,这些相关性似乎在女性、老年人、体重指数(BMI)较高者和糖尿病患者中更强。DPHP 和 DBUP 的剂量反应曲线呈上升趋势。相比之下,BCEP 和 BCPP 与患 RA 的概率呈 U 型关系和倒 U 型关系。BDCPP 的关系复杂,在浓度较低时达到峰值,随后下降。最后,我们的研究还得出结论,暴露于 OPEs 在 RA 的发病机制中起着至关重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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