medRxiv - Rheumatology

Mosaic loss of chromosome Y characterizes late-onset rheumatoid arthritis and contrasting associations of polygenic risk score based on age at onset.

Pub Date : 2024-09-13 DOI: 10.1101/2024.09.12.24313215 Shunsuke Uchiyama, Yuki Ishikawa, Katsunori Ikari, Suguru Honda, Keiko Hikino, Eiichi Tanaka, Yoichiro Kamatani, Takahisa Gono, Giulio Genovese, Masataka Kuwana, Chikashi Terao

Use of Metagenomic Microbial Plasma Cell-Free DNA Next-Generation Sequencing Assay in Outpatient Rheumatology Practice

Pub Date : 2024-09-11 DOI: 10.1101/2024.09.09.24313356 Rachel Jenkins, Matthew Samec, Courtney Arment, Kenneth J Warrington, John M Davis, Matthew J Koster

Proteomic profiling of the large vessel vasculitis spectrum identifies shared signatures of innate immune activation and stromal remodelling

Pub Date : 2024-09-07 DOI: 10.1101/2024.09.06.24313218 Robert T Maughan, Erin MacDonald-Dunlop, Lubna Haroon-Rashid, Louise Sorensen, Natalie Chaddock, Shauna Masters, Andrew Porter, Marta Peverelli, Charis Pericleous, Andrew Hutchings, James Robinson, Taryn Youngstein, Raashid Luqmani, Justin C. Mason, Ann W Morgan, James E Peters