Innovative Nickel Oxide-Pluronic F127-Escin Hybrids: Synthesis, Characterization, and Dual Bioactivity Against Bacteria and Cancer Cells

IF 3.9 3区化学 Q2 POLYMER SCIENCE

Journal of Inorganic and Organometallic Polymers and Materials Pub Date : 2024-08-31 DOI:10.1007/s10904-024-03347-2

P. Baby Shakila, Muruganantham Bharathi, Nouf M. Alyami, Sulaiman Ali Alharbi, Samer Hasan Hussein-Al-Ali, Saravana Kumar Jaganathan, Palanisamy Arulselvan

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Abstract

The present work focused on synthesizing and characterizing nickel oxide-Pluronic127-Escin hybrid nanomaterials (NiO-PF127-Escin HNMs) and evaluating their antibacterial and cytotoxic properties against cervical (HeLa) and liver cancer (Hep3B) cells. The NiO-PF127-Escin HNMs were synthesized using a chemical precipitation process. XRD patterns revealed that the synthesized NiO-PF127-Escin HNMs exhibit a face-centered cubic structure with an average crystalline size of 42 nm. TEM analysis showed that the NiO-PF127-Escin HNMs formed a rod-like structure. The elemental composition of the hybrid materials, including Ni, O, and C, was identified by EDX spectrum analysis. DLS results indicated an average particle size of 145.90 nm, and UV–Vis spectral analysis revealed a maximum absorbance at 302 nm, confirming the formation of NiO-PF127-Escin HNMs. Various surface defects of the NiO-PF127-Escin HNMs were analyzed using PL. The NiO-PF127-Escin HNMs exhibited potential antibacterial activity against gram-negative bacterial strains. Additionally, NiO-PF127-Escin HNMs significantly inhibited the viability of both Hep3B and HeLa cells. The results suggest that NiO-PF127-Escin HNMs possess potent antibacterial and cytotoxic properties.

Graphical Abstract

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创新性氧化镍-聚羧酸 F127-霉素杂化物：针对细菌和癌细胞的合成、表征和双重生物活性

本研究的重点是合成和表征氧化镍-Pluronic127-Escin 杂化纳米材料（NiO-PF127-Escin HNMs），并评估其对宫颈癌（HeLa）和肝癌（Hep3B）细胞的抗菌性和细胞毒性。NiO-PF127-Escin HNMs 采用化学沉淀法合成。XRD 图谱显示，合成的 NiO-PF127-Escin HNMs 呈面心立方结构，平均结晶尺寸为 42 nm。TEM 分析表明，NiO-PF127-Escin HNMs 形成了棒状结构。混合材料的元素组成（包括 Ni、O 和 C）是通过 EDX 光谱分析确定的。DLS 结果显示平均粒径为 145.90 nm，紫外可见光谱分析显示最大吸光度为 302 nm，证实了 NiO-PF127-Escin HNMs 的形成。利用聚光光谱分析了 NiO-PF127-Escin HNMs 的各种表面缺陷。NiO-PF127-Escin HNMs 对革兰氏阴性细菌菌株具有潜在的抗菌活性。此外，NiO-PF127-Escin HNMs 还能显著抑制 Hep3B 和 HeLa 细胞的活力。这些结果表明，NiO-PF127-Escin HNMs 具有很强的抗菌性和细胞毒性。

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来源期刊

Journal of Inorganic and Organometallic Polymers and Materials 化学-高分子科学

CiteScore

8.30

自引率

7.50%

发文量

335

审稿时长

1.8 months

期刊介绍： Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.