Visual-Based Platform Using Sustainable Intrinsic Fluorescent Zn-Based Metal–Organic Framework for Detection of Folic Acid in Pharmaceutical Formulations

IF 3.9 3区化学 Q2 POLYMER SCIENCE

Journal of Inorganic and Organometallic Polymers and Materials Pub Date : 2024-08-19 DOI:10.1007/s10904-024-03322-x

Idrees B. Qader, Sameera Sh. Mohammed Ameen, Hemn A. Qader, Khalid M. Omer

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Abstract

In the present work, intrinsic fluorescent zinc-based metal–organic framework (FMOF-5) was prepared and used for folic acid (FA) detection. The intrinsic emission of zinc-based MOFs without encapsulation and/or functionalization of the ligand and/or the MOF is not very common. Here, the intrinsic emission of FMOF-5 is triggered by the coordination-induced emission of weakly fluorescent organic ligand in the framework structure. FMOF-5 showed fluorescence emission at 440 nm when excited at 300 nm. Common characterization techniques were used to investigate the size, morphology, and optical properties of the FMOF-5. The fluorescence emission of the prepared MOF was quenched by the internal filter effect, which gives us an opportunity to design a novel on-off mode sensor for the detection of FA. The conventional fluorometric-based assay and the smartphone-assisted visual detection mode were developed and validated. The visual-mode linearity was from 30 to 270 µM with limit of detection about 4.3 µM. The on-off sensor was successfully applied for detection of FA in pharmaceutical formulations with excellent recovery and reproducibility. The visual on-off mode using intrinsic fluorescent MOFs is highly appealing for pint of care testing applications.

Graphical Abstract

Abstract Image

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利用可持续本征荧光锌基金属有机框架的可视化平台检测药物制剂中的叶酸

本研究制备了本征荧光锌基金属有机框架（FMOF-5），并将其用于叶酸（FA）检测。锌基金属有机框架在没有对配体和/或 MOF 进行封装和/或功能化的情况下实现本征发射并不常见。在这里，FMOF-5 的本征发射是由框架结构中弱荧光有机配体的配位诱导发射引发的。在 300 纳米波长下激发时，FMOF-5 发出 440 纳米波长的荧光。利用常见的表征技术研究了 FMOF-5 的尺寸、形态和光学特性。制备的 MOF 的荧光发射被内部滤光器效应淬灭，这为我们设计一种新型的开关模式传感器检测 FA 提供了机会。我们开发并验证了传统的荧光测定法和智能手机辅助的视觉检测模式。视觉模式的线性范围为 30 至 270 µM，检测限约为 4.3 µM。该开关传感器成功应用于药物制剂中 FA 的检测，回收率和重现性极佳。使用本征荧光 MOFs 的可视开关模式在护理检测应用中极具吸引力。

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来源期刊

Journal of Inorganic and Organometallic Polymers and Materials 化学-高分子科学

CiteScore

8.30

自引率

7.50%

发文量

335

审稿时长

1.8 months

期刊介绍： Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.