Injectable thermosensitive microsphere-hydrogel composite system: combined therapy of hepatocellular carcinoma by remodeling tumor immune microenvironment

IF 6.8 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Science China Materials Pub Date : 2024-08-26 DOI:10.1007/s40843-024-3001-3

Jinghan Liao (, ), Zhihua Wu (, ), Yijie Qiu (, ), Fangqin Xue (, ), Ke Gong (, ), Yi Duan (, ), Chao Xu (, ), Bin Liu (, ), Jiangtao Lin (, ), Yi Dong (, ), Ying Sun (, ), Yourong Duan (, )

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引用次数: 0

Abstract

Advanced hepatocellular carcinoma (HCC) is one of the most prevalent malignancies, and the clinical treatment outcomes are not satisfactory. Due to the complexity, heterogeneity, and immunosuppressive microenvironment of HCC, monotherapies have limited effects. Therefore, combined therapy may effectively enhance antitumor treatment by remodeling the tumor immune microenvironment. This study reports an injectable thermosensitive microsphere-hydrogel composite system for local co-delivery of the targeted drug sorafenib (SOR) and immunomodulatory cytokines for the combined therapy of HCC. The delivery system exhibited superior properties such as dual-drug delivery, sustained and slow release, local injectability, thermosensitivity, and low side effects. Moreover, it successfully remodeled the immune microenvironment of HCC by increasing the infiltration of CD8⁺ T cells and natural killer cells while decreasing the infiltration of immunosuppressive Treg cells, thereby achieving a potent synergistic effect with SOR. This safe composite delivery system can remodel the tumor microenvironment and enhance anti-tumor treatment, providing a valuable option for the treatment of HCC.

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可注射热敏微球-水凝胶复合系统：通过重塑肿瘤免疫微环境联合治疗肝细胞癌

晚期肝细胞癌（HCC）是最常见的恶性肿瘤之一，临床治疗效果并不理想。由于 HCC 的复杂性、异质性和免疫抑制微环境，单一疗法的效果有限。因此，联合治疗可通过重塑肿瘤免疫微环境，有效提高抗肿瘤治疗效果。本研究报告了一种可注射的热敏微球-水凝胶复合系统，用于局部联合给药靶向药物索拉非尼（SOR）和免疫调节细胞因子，以联合治疗 HCC。该给药系统具有双药给药、持续缓释、局部注射、热敏性和低副作用等优越性能。此外，它还通过增加 CD8+ T 细胞和自然杀伤细胞的浸润，同时减少免疫抑制性 Treg 细胞的浸润，成功重塑了 HCC 的免疫微环境，从而实现了与 SOR 的强效协同作用。这种安全的复合给药系统可以重塑肿瘤微环境，提高抗肿瘤治疗效果，为治疗 HCC 提供了一种有价值的选择。

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来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.