Application of Fe3O4@MCC Nanoparticles as a Heterogeneous Catalyst for Sustainable Multicomponent Synthesis of 2,3'‐Biindoles

IF 3.8 3区化学 Q2 CHEMISTRY, PHYSICAL

ChemCatChem Pub Date : 2024-09-04 DOI:10.1002/cctc.202401308

Ajay U. Pandya, Mukesh P. Chaudhari, Vinay S. Sharma, Archana George, Gopal N. Shiyal, Pranav S Shrivastav

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引用次数: 0

Abstract

Developing innovative methods for synthesizing unique 2,3'‐biindole derivatives is crucial for the progression of drug and material discovery. The use of transition‐metal‐catalyzed coupling improves the efficiency and structural diversity in the synthesis of biindoles. Among these methods, heterogeneous catalysis, particularly using Fe3O4 nanocatalyst supported by microcrystalline cellulose (MCC), is promising for green chemistry applications. In the present work, sixteen 2,3'‐biindole derivatives (4a‐p) were prepared using Fe3O4@MCC nano catalyst which demonstrated enhanced performance, cost‐effectiveness, and reusability. The magnetic properties of the catalyst enable easy separation, simplifying purification processes and enhancing overall reaction efficiency to 78‐93%. This method aligns with sustainable chemical practices and offers practical benefits for various industrial applications. This environmentally friendly method boasts several advantages and demonstrates excellent green chemistry metrics, including process mass intensity, environmental impact factor, atom economy, and reaction mass efficiency, atom economy, carbon efficiency, chemical yield and optimum efficiency.

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应用 Fe3O4@MCC 纳米颗粒作为可持续多组分合成 2,3'-联吲哚的异构催化剂

开发合成独特的 2,3'-联吲哚衍生物的创新方法对于药物和材料的发现至关重要。使用过渡金属催化偶联提高了合成生物吲哚的效率和结构多样性。在这些方法中，异相催化，特别是使用微晶纤维素（MCC）支撑的 Fe3O4 纳米催化剂，在绿色化学应用中大有可为。在本研究中，使用 Fe3O4@MCC 纳米催化剂制备了 16 种 2,3'-联吲哚衍生物 (4a-p)，这些衍生物具有更高的性能、成本效益和可重复使用性。催化剂的磁性使其易于分离，简化了纯化过程，并将整体反应效率提高到 78-93%。这种方法符合可持续化学实践，为各种工业应用提供了实际效益。这种环境友好型方法具有多项优势，并展示了出色的绿色化学指标，包括过程质量强度、环境影响因子、原子经济性、反应质量效率、原子经济性、碳效率、化学收率和最佳效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemCatChem 化学-物理化学

CiteScore

8.10

自引率

4.40%

发文量

511

审稿时长

1.3 months

期刊介绍： With an impact factor of 4.495 (2018), ChemCatChem is one of the premier journals in the field of catalysis. The journal provides primary research papers and critical secondary information on heterogeneous, homogeneous and bio- and nanocatalysis. The journal is well placed to strengthen cross-communication within between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and is supported by the German Catalysis Society.