Preparation and biocompatibility of collagen surface-modified styrene-isobutylene-styrene

IF 2.6 4区化学 Q3 POLYMER SCIENCE

Journal of Polymer Research Pub Date : 2024-08-21 DOI:10.1007/s10965-024-04106-0

Minhan Chen, Yushun Jin, Ruofan Liu, Hao Zhang, Yanhong Song, Wei Ding, Jiwei Li, Yibo Wu

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Abstract

Styrene-Isobutylene-Styrene (SIBS) is a high-performance biocompatible elastomeric material. However, its low surface energy and hydrophobic nature limit its widespread application in the field of implantable materials within the human body. In this study, UV-initiated polymerization was employed to prepare SIBS-acrylic acid surface-grafted co-polymer. Subsequently, collagen protein (Coll) surface modification of SIBS was achieved through a coupling reaction with acrylic acid, resulting in the production of Collagen Surface-Modified SIBS, denoted as SIBS-AA-Coll. Characterization was carried out using techniques such as infrared spectroscopy, thermal analysis, scanning electron microscopy, X-ray photoelectron spectroscopy (XPS), and water contact angle measurements. The results demonstrated that, with a UV exposure time of 4 min and a n_BP:n_AA ratio of 15:100, the grafting ratio reached 9.4%, significantly improving the hydrophilicity of the SIBS surface. In vitro cytotoxicity tests and in vivo animal implantation experiments indicated that Collagen Surface-Modified SIBS exhibited excellent biocompatibility.

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胶原表面改性苯乙烯-异丁烯-苯乙烯的制备与生物相容性

苯乙烯-异丁烯-苯乙烯（SIBS）是一种高性能的生物相容性弹性材料。然而，其较低的表面能和疏水性限制了它在人体植入材料领域的广泛应用。本研究采用紫外线引发聚合法制备 SIBS-丙烯酸表面接枝共聚物。随后，通过与丙烯酸的偶联反应对 SIBS 进行胶原蛋白（Coll）表面改性，制备出胶原蛋白表面改性 SIBS，简称 SIBS-AA-Coll。利用红外光谱、热分析、扫描电子显微镜、X 射线光电子能谱（XPS）和水接触角测量等技术进行了表征。结果表明，紫外线照射时间为 4 分钟，nBP:nAA 的比例为 15:100，接枝率达到 9.4%，显著提高了 SIBS 表面的亲水性。体外细胞毒性测试和体内动物植入实验表明，胶原表面改性 SIBS 具有良好的生物相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Polymer Research 化学-高分子科学

CiteScore

4.70

自引率

7.10%

发文量

472

审稿时长

3.6 months

期刊介绍： Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including: polymer synthesis; polymer reactions; polymerization kinetics; polymer physics; morphology; structure-property relationships; polymer analysis and characterization; physical and mechanical properties; electrical and optical properties; polymer processing and rheology; application of polymers; supramolecular science of polymers; polymer composites.