Sequentially crosslinked collagen‐based hydrogel to form a semi‐interpenetrating network for enhanced stability to hydrolytic degradation and electrochemical properties

IF 3.1 4区工程技术 Q2 POLYMER SCIENCE

Polymers for Advanced Technologies Pub Date : 2024-08-16 DOI:10.1002/pat.6546

Shahemi Nur Hidayah, Ahmad Ruzaidi Dania Adila, Ab Rahim Sharaniza, Amir Muhammad Abid, Mahat Mohd Muzamir

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引用次数: 0

Abstract

Biodegradable polymers are pivotal in tissue engineering, facilitating long‐term tissue reintegration and reducing the necessity for surgery. However, collagen, a crucial component of the extracellular matrix, encountered challenges due to its limited mechanical strength and rapid in‐vivo degradation. This study addresses these issues through crosslinking and functionalizing collagen with synthetic 4‐arm amine‐terminated polyethylene glycol (PEG) in a semi‐interpenetrating network (IPN) hydrogel. The first goal is to enhance resistance to hydrolysis, thus extending the biodegradation rate. Then, to explore its electrical conductivity properties for certain applications like neural tissue regeneration. The hydrogels were fabricated using sequential IPN formation synthesis where their structural stability and type of degradation by‐products were confirmed using Fourier‐transform infrared spectroscopy (FTIR), Raman spectroscopy, scanning electron microscopy (SEM), and nuclear magnetic resonance (NMR). Next, its mechanical and degradation properties investigations exhibit a 92% enhancement in hardness and a 90% retainment of its initial mass over time under physiological conditions. Additionally, the introduction of polypyrrole (PPy) via in‐situ polymerization increases its electrical conductivity, achieving a remarkable 104‐fold increase at a 0.75 M concentration, attributed to the interconnectivity of PPy chain networks within the three‐dimensional structure of IPN collagen/PEG hydrogel. The increased PPy concentration improves conductivity and reduces energy requirements for redox reactions, ensuring electrochemical stability as revealed by cyclic voltammetry analysis. The demonstrated structural and electrochemical stability of the semi‐IPN collagen/PEG/PPy hydrogel within a physiological environment through a facile sequential crosslinking method underscores its promising practical applications in enhancing clinical effectiveness.

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顺序交联胶原基水凝胶，形成半互穿网络，增强水解降解稳定性和电化学性能

生物可降解聚合物在组织工程学中起着举足轻重的作用，可促进组织的长期重新整合，减少手术的必要性。然而，作为细胞外基质的重要组成部分，胶原蛋白因其有限的机械强度和体内快速降解而面临挑战。本研究通过在半互穿网络（IPN）水凝胶中用合成的 4 臂胺端聚乙二醇（PEG）交联和功能化胶原蛋白来解决这些问题。首要目标是提高抗水解性，从而延长生物降解率。然后，探索其导电性能，以用于神经组织再生等特定应用。水凝胶的制造采用了 IPN 有序形成合成法，并利用傅立叶变换红外光谱（FTIR）、拉曼光谱、扫描电子显微镜（SEM）和核磁共振（NMR）确认了其结构稳定性和降解副产物的类型。接着，对其机械性能和降解性能的调查显示，在生理条件下，随着时间的推移，其硬度提高了 92%，初始质量保持率达到 90%。此外，通过原位聚合引入聚吡咯（PPy）可提高其导电性，在 0.75 M 浓度时，导电性显著提高了 104 倍，这归功于 IPN 胶原/PEG 水凝胶三维结构中的 PPy 链网络的相互连接性。PPy 浓度的增加提高了导电性，降低了氧化还原反应的能量需求，确保了循环伏安分析所显示的电化学稳定性。通过简便的顺序交联方法，半 IPN 胶原/PEG/PPy 水凝胶在生理环境中的结构和电化学稳定性得到了证实，这突出表明它在提高临床疗效方面具有广阔的实际应用前景。

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来源期刊

Polymers for Advanced Technologies 工程技术-高分子科学

CiteScore

6.20

自引率

5.90%

发文量

337

审稿时长

2.1 months

期刊介绍： Polymers for Advanced Technologies is published in response to recent significant changes in the patterns of materials research and development. Worldwide attention has been focused on the critical importance of materials in the creation of new devices and systems. It is now recognized that materials are often the limiting factor in bringing a new technical concept to fruition and that polymers are often the materials of choice in these demanding applications. A significant portion of the polymer research ongoing in the world is directly or indirectly related to the solution of complex, interdisciplinary problems whose successful resolution is necessary for achievement of broad system objectives. Polymers for Advanced Technologies is focused to the interest of scientists and engineers from academia and industry who are participating in these new areas of polymer research and development. It is the intent of this journal to impact the polymer related advanced technologies to meet the challenge of the twenty-first century. Polymers for Advanced Technologies aims at encouraging innovation, invention, imagination and creativity by providing a broad interdisciplinary platform for the presentation of new research and development concepts, theories and results which reflect the changing image and pace of modern polymer science and technology. Polymers for Advanced Technologies aims at becoming the central organ of the new multi-disciplinary polymer oriented materials science of the highest scientific standards. It will publish original research papers on finished studies; communications limited to five typewritten pages plus three illustrations, containing experimental details; review articles of up to 40 pages; letters to the editor and book reviews. Review articles will normally be published by invitation. The Editor-in-Chief welcomes suggestions for reviews.