Novel drug delivery materials: Chitosan polymers conjugated with Spondias pinnata phytocompounds for enhanced anti‐microbial and anti‐cancer properties

IF 3.1 4区工程技术 Q2 POLYMER SCIENCE

Polymers for Advanced Technologies Pub Date : 2024-09-05 DOI:10.1002/pat.6561

M. Gomathi, Nair Deepa, Aiswarya Muraleedharan, Shanmugavel Uma Maheswari, R. Thirumalaisamy, T. Selvankumar, Arunachalam Chinnathambi, Sulaiman Ali Alharbi

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引用次数: 0

Abstract

The current study aimed to investigate the drug delivery potential of chitosan‐conjugated Spondias pinnata phytocompounds for anticancer and antibacterial applications. The phytochemical composition of the aqueous extract of S. pinnata plant leaves revealed seven major compounds, including stearic acid, 2H‐Indol‐2‐one, beta amyrin, oleic acid, octadecanoic acid, 7‐hexadecenoic acid, and phytol. Additionally, five minor compounds were identified through GC–MS analysis. SEM analysis of chitosan‐conjugated S. pinnata phytocompounds revealed amorphous particles. This demonstrates the attainment of optimized larger crystallites, which differ in size and shape extensively. The antioxidant potential of both the chitosan‐conjugated S. pinnata phytocompounds and S. pinnata leaf extracts was evaluated via DPPH and ABTS assays, and the results revealed that the chitosan‐conjugated S. pinnata phytocompounds exhibited significant scavenging activity, with IC50 values of 18.20 and 33.15 μg/mL, respectively. Chitosan‐conjugated S. pinnata phytocompounds also demonstrated antibacterial activity against four clinically significant infections, with zones of inhibition ranging from 16 ± 0.07, 19 ± 0.10, 17 ± 0.09, and 19 ± 0.11 mm against Escherichia coli (MTCC 452), Salmonella typhi (MTCC 733), Klebsiella pneumonia (MTCC 39), and Pseudomonas aeruginosa (MTCC 1688), respectively. Furthermore, the cytotoxicity of the chitosan‐conjugated S. pinnata phytocompounds was assessed against A549 lung cancer cells, and the results revealed a significant reduction in cell viability (33.85) at higher concentrations of 150 μg/mL. The IC50 values of S. pinnata leaf extract (149.2 mg/mL) and chitosan‐conjugated S. pinnata (126.4 mg/mL) toward A549 lung cancer cells were recorded. Overall, the results of the present study highlight the therapeutic applications of chitosan‐conjugated S. pinnata phytocompounds, particularly in the context of their anticancer and antibacterial activities.

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新型给药材料：壳聚糖聚合物与羽扇豆植物化合物共轭，增强抗微生物和抗癌特性

本研究旨在探讨壳聚糖共轭的羽扇豆植物化合物在抗癌和抗菌应用中的给药潜力。研究发现，羽扇豆叶水提取物的植物化学成分中含有七种主要化合物，包括硬脂酸、2H-吲哚-2-酮、β-吡喃酮、油酸、十八酸、7-十六烯酸和植物醇。此外，还通过气相色谱-质谱分析确定了五种次要化合物。对壳聚糖共轭的羽扇豆植物化合物进行的扫描电镜分析表明，其为无定形颗粒。这表明已获得优化的较大结晶，其大小和形状差异很大。通过 DPPH 和 ABTS 试验评估了壳聚糖共轭羽扇豆植物化合物和羽扇豆叶提取物的抗氧化潜力，结果表明壳聚糖共轭羽扇豆植物化合物具有显著的清除活性，IC50 值分别为 18.20 和 33.15 μg/mL。壳聚糖共轭的羽扇豆植物化合物还对四种具有临床意义的感染表现出抗菌活性，对大肠杆菌（MTCC 452）、伤寒沙门氏菌（MTCC 733）、肺炎克雷伯氏菌（MTCC 39）和铜绿假单胞菌（MTCC 1688）的抑制区分别为 16 ± 0.07 毫米、19 ± 0.10 毫米、17 ± 0.09 毫米和 19 ± 0.11 毫米。此外，还评估了壳聚糖结合的羽扇豆植物化合物对 A549 肺癌细胞的细胞毒性，结果表明，在 150 μg/mL 的较高浓度下，细胞活力显著降低（33.85）。羽扇豆叶提取物（149.2 毫克/毫升）和壳聚糖结合的羽扇豆叶提取物（126.4 毫克/毫升）对 A549 肺癌细胞的 IC50 值均有记录。总之，本研究的结果突出了壳聚糖共轭羽扇豆植物化合物的治疗应用，尤其是在抗癌和抗菌活性方面。

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来源期刊

Polymers for Advanced Technologies 工程技术-高分子科学

CiteScore

6.20

自引率

5.90%

发文量

337

审稿时长

2.1 months

期刊介绍： Polymers for Advanced Technologies is published in response to recent significant changes in the patterns of materials research and development. Worldwide attention has been focused on the critical importance of materials in the creation of new devices and systems. It is now recognized that materials are often the limiting factor in bringing a new technical concept to fruition and that polymers are often the materials of choice in these demanding applications. A significant portion of the polymer research ongoing in the world is directly or indirectly related to the solution of complex, interdisciplinary problems whose successful resolution is necessary for achievement of broad system objectives. Polymers for Advanced Technologies is focused to the interest of scientists and engineers from academia and industry who are participating in these new areas of polymer research and development. It is the intent of this journal to impact the polymer related advanced technologies to meet the challenge of the twenty-first century. Polymers for Advanced Technologies aims at encouraging innovation, invention, imagination and creativity by providing a broad interdisciplinary platform for the presentation of new research and development concepts, theories and results which reflect the changing image and pace of modern polymer science and technology. Polymers for Advanced Technologies aims at becoming the central organ of the new multi-disciplinary polymer oriented materials science of the highest scientific standards. It will publish original research papers on finished studies; communications limited to five typewritten pages plus three illustrations, containing experimental details; review articles of up to 40 pages; letters to the editor and book reviews. Review articles will normally be published by invitation. The Editor-in-Chief welcomes suggestions for reviews.