There and back again: Discovering antiviral and antiphage defenses using deep homology

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-09-11 DOI:10.1016/j.chom.2024.08.006

Edward M. Culbertson, Tera C. Levin

引用次数: 0

Abstract

Two recent studies in Cell Host & Microbe (Cury et al. and van den Berg et al.) uncover cross-kingdom links between antiphage and antiviral immune defenses. Through reciprocal computational and wet lab approaches, they each discover and experimentally validate proteins used for host immunity.

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去而复返：利用深度同源性发现抗病毒和抗蚜虫防御系统

细胞宿主与amp; 微生物》（Cell Host & Microbe）杂志最近的两项研究（Cury 等人和 van den Berg 等人）发现了抗虹吸和抗病毒免疫防御之间的跨领域联系。通过相互计算和湿实验室方法，他们各自发现并通过实验验证了用于宿主免疫的蛋白质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.