Low-cost electrochemical sensor for ciprofloxacin antibiotic based on green-synthesized silver nanoparticles and carbon black

IF 2.6 4区 化学 Q3 ELECTROCHEMISTRY
Laís Muniz Meireles, Rafael Matias Silva, Renê Chagas da Silva, Leonardo Luiz Okumura, Renata Pereira Lopes Moreira, Tiago Almeida Silva
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Abstract

An unprecedented electrochemical sensor based on low-cost films combining carbon black (CB) and green-synthesized silver nanoparticles (AgNPs) is proposed for the voltammetric determination of ciprofloxacin, an antibiotic widely used in the treatment of infectious diseases. AgNPs were biosynthesized by using an aqueous plant extract of Camellia sinensis (black tea) in which the metabolites worked as reducing and stabilizing agents. The AgNPs and CB nanoparticles were incorporated within a crosslinked chitosan (Ch) film over the surface of a glassy carbon electrode (GCE). The nanomaterials were characterized by scanning electron microscopy (SEM), ultraviolet–visible molecular absorption spectrophotometry (UV–Vis), dynamic light scattering (DLS), zeta potential, and cyclic voltammetry (CV). The sensor modified with both nanomaterials (AgNPs-CB-Ch/GCE) showed a significatively enhanced analytical signal for the ciprofloxacin irreversible oxidation peak. Using square-wave voltammetry (SWV) under the optimized working conditions and the proposed AgNPs-CB-Ch/GCE sensor, the analytical curve displayed two linear concentration ranges of 3.1 to 24.8 µmol L−1 and of 36.9 to 130.3 µmol L−1, with a limit of detection of 0.48 µmol L−1. The proposed electrochemical sensor presented good precision as shown from repeatability tests, as well as it was successfully applied in the quantification of ciprofloxacin in the synthetic urine sample, with recovery results close to 100% for both linear concentration ranges. The presented AgNPs synthetic method and CIP electrochemical detection are found to be simple and efficient compared to the conventional methods commonly reported.

Abstract Image

基于绿色合成银纳米粒子和炭黑的低成本环丙沙星抗生素电化学传感器
本文提出了一种前所未有的电化学传感器,该传感器基于碳黑(CB)和绿色合成银纳米粒子(AgNPs)的低成本薄膜,用于伏安法测定环丙沙星,环丙沙星是一种广泛用于治疗传染病的抗生素。AgNPs 是利用茶树(红茶)的水性植物提取物进行生物合成的,其中的代谢产物可作为还原剂和稳定剂。AgNPs和CB纳米颗粒被纳入玻璃碳电极(GCE)表面的交联壳聚糖(Ch)薄膜中。通过扫描电子显微镜(SEM)、紫外可见光分子吸收分光光度法(UV-Vis)、动态光散射(DLS)、ZETA 电位和循环伏安法(CV)对纳米材料进行了表征。用这两种纳米材料修饰的传感器(AgNPs-CB-Ch/GCE)显示出环丙沙星不可逆氧化峰的分析信号明显增强。在优化的工作条件下使用方波伏安法(SWV)和拟议的 AgNPs-CB-Ch/GCE 传感器,分析曲线显示出 3.1 至 24.8 µmol L-1 和 36.9 至 130.3 µmol L-1 两个线性浓度范围,检测限为 0.48 µmol L-1。重复性测试表明,所提出的电化学传感器具有良好的精度,并成功地应用于合成尿样中环丙沙星的定量分析,在两个线性浓度范围内的回收率均接近 100%。与常见的传统方法相比,本文介绍的 AgNPs 合成方法和 CIP 电化学检测方法简单高效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
4.00%
发文量
227
审稿时长
4.1 months
期刊介绍: The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry. The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces. The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis. The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.
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