In‐Situ and Green Synthesis of Silk Fibroin‐Silver Nanoparticles Composite Microfibers for Enhanced Antibacterial Applications

IF 3 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Rui Zhang, Dandan Luo, Mohammad Jaber, Han ZHANG, Xiangdong Kong
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引用次数: 0

Abstract

The antibacterial properties of modified silk fibroin microfibers (SF MFs) have been widely studied. Among various modifications, integration of silver nanoparticles (Ag NPs) and SF MFs has garnered significant attention due to the broad‐spectrum antibacterial activities and long‐term antibacterial effect of Ag nanomaterials. However, the traditional introduction of reducing agents or other additives during the synthesis of Ag‐SF composite MFs potentially affects their structure and antibacterial properties. Facile, green and effective methods for the preparation of Ag‐SF MFs with enhanced antibacterial properties are therefore highly desired. In this study, Ag NPs were uniformly in‐situ deposited onto the optimized SF MFs by adjusting the pH and duration conditions under the guidance of green chemistry. The loaded Ag NPs have a good dispersibility and an average size of ~10 nm. The stability of SF MFs after the deposition of Ag NPs and the crystalline features of the loaded Ag NPs have been carefully investigated. Moreover, antibacterial experiments confirmed that Ag‐SF MFs exhibited superior antibacterial activities. After co‐incubating Ag‐SF MFs with L929 cells, the cell viability reached 90%, demonstrating the great biocompatibility of the modified fibers. This green in‐situ synthetic method will promote the further medical use of Ag‐SF MFs in antibacterial fields.
原位绿色合成蚕丝纤维素-银纳米颗粒复合微纤维以增强抗菌应用
改性蚕丝纤维(SF MFs)的抗菌特性已被广泛研究。在各种改性中,银纳米粒子(Ag NPs)与蚕丝复合纤维的结合引起了广泛关注,因为银纳米材料具有广谱抗菌活性和长期抗菌效果。然而,在合成 Ag-SF 复合 MFs 的过程中,传统的还原剂或其他添加剂的引入可能会影响其结构和抗菌性能。因此,制备具有更强抗菌性能的 Ag-SF MFs 的简便、绿色和有效方法备受青睐。本研究在绿色化学的指导下,通过调节 pH 值和时间条件,将 Ag NPs 均匀地原位沉积到优化的 SF MFs 上。负载的 Ag NPs 具有良好的分散性,平均尺寸约为 10 nm。研究人员仔细考察了沉积 Ag NPs 后 SF MF 的稳定性和负载 Ag NPs 的结晶特征。此外,抗菌实验证实,Ag-SF MFs 具有优异的抗菌活性。将 Ag-SF MFs 与 L929 细胞共培养后,细胞存活率达到 90%,表明改性纤维具有良好的生物相容性。这种绿色原位合成方法将促进 Ag-SF MFs 在抗菌领域的进一步医疗应用。
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来源期刊
ChemPlusChem
ChemPlusChem CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
5.90
自引率
0.00%
发文量
200
审稿时长
1 months
期刊介绍: ChemPlusChem is a peer-reviewed, general chemistry journal that brings readers the very best in multidisciplinary research centering on chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. Fully comprehensive in its scope, ChemPlusChem publishes articles covering new results from at least two different aspects (subfields) of chemistry or one of chemistry and one of another scientific discipline (one chemistry topic plus another one, hence the title ChemPlusChem). All suitable submissions undergo balanced peer review by experts in the field to ensure the highest quality, originality, relevance, significance, and validity.
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