Acrylamide exposure, sex hormones, and pubertal status in Japanese adolescents.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-09-10 DOI:10.1080/09603123.2024.2401578

Chisato Nagata,Keiko Wada,Michiyo Yamakawa,Masaaki Sugino,Tomoka Mori,Jun Ueyama,Yoshio Sumoto

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引用次数: 0

Abstract

Acrylamide may affect sex hormone levels and the timing of sexual maturation. The present study cross-sectionally examined interrelationship between the urinary metabolite of acrylamide exposure, serum sex hormone levels, and pubertal status in 408 Japanese adolescents aged 13-14 years. Their caregivers completed a questionnaire concerning the health status of their children, including pubertal maturation, and the lifestyles of children and parents. Pubertal status was queried by the Pubertal Development Scale. A major metabolite of acrylamide, N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) in first-void urine samples. In male students, urinary AAMA was significantly inversely associated with testosterone, puberty stage, and facial hair growth after controlling for covariates. Serum testosterone and DHEAS were significantly positively associated with puberty stage. In female students, urinary AAMA was not associated with puberty stage, the indices, or any measured hormones. The data suggest that exposure to acrylamide may impact the pubertal development of boys through the effects on testosterone level.

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日本青少年接触丙烯酰胺的情况、性激素和青春期状况。

丙烯酰胺可能会影响性激素水平和性成熟的时间。本研究对 408 名 13-14 岁日本青少年尿液中丙烯酰胺代谢物、血清性激素水平和青春期状况之间的相互关系进行了横断面研究。他们的看护人填写了一份调查问卷，内容涉及子女的健康状况（包括青春期成熟情况）以及子女和父母的生活方式。青春期发育状况通过青春期发育量表进行调查。丙烯酰胺的主要代谢产物 N-乙酰基-S-（2-氨基甲酰乙基）-半胱氨酸（AAMA）在第一次排尿样本中的含量。在男性学生中，尿液中的丙烯酰胺与睾酮、青春期阶段和面部毛发生长显著成反比。血清睾酮和 DHEAS 与青春期阶段呈显著正相关。在女生中，尿液中的 AAMA 与青春期阶段、各项指数或任何测得的激素均无关联。数据表明，接触丙烯酰胺可能会影响睾酮水平，从而影响男孩的青春期发育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.