{"title":"Striatum is the potential target for treating absence epilepsy: a theoretical evidence","authors":"Bing Hu, Weiting Zhou, Xunfu Ma","doi":"10.1007/s11571-024-10161-6","DOIUrl":null,"url":null,"abstract":"<p>The output of the basal ganglia to the corticothalamic system plays an important role in regulating absence seizures. Inspired by experiments, we systematically study the crucial roles of two newly identified direct inhibitory striatal-cortical projections that project from the striatal D1 nucleus (SD1) and striatal D2 nucleus (SD2) to the cerebral cortex, in controlling absence seizures. Through computational simulation, we observe that typical 2–4 Hz spike and wave discharges (SWDs) can be induced through the pathological mechanism of cortical circuits, and both enhancing the inhibitory coupling weight on the striatal-cortical projections and improving the discharge activation level of striatal populations can effectively control typical SWDs. Furthermore, typical SWDs can be suppressed by appropriately adjusting several input projections directly related to the striatum, through regulating the activation level of striatal populations. Interestingly, several indirect striatum-related basal ganglia projections also have significant effects on the inhibition of typical SWDs, through the direct inhibitory striatal-cortical projections. Both the unidirectional control mode and bidirectional control mode for typical SWDs exist in our modified model. Importantly, the enhancement of coupling strengths on inhibitory striatal-cortical projections is beneficial for suppressing SWDs and may play a decisive regulatory role in the formation of control modes. Therefore, our study suggests that striatum may be potential effective targets for the treatment of absence seizures, through two newly identified direct inhibitory striatal-cortical projections. Interestingly, we find that external stimuli simultaneously targeting the striatum and another basal ganglia nucleus have a better control effect on SWDs than targeting a single basal ganglia nucleus, and the obtained results provide testable hypotheses for future experiments.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cognitive Neurodynamics","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s11571-024-10161-6","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The output of the basal ganglia to the corticothalamic system plays an important role in regulating absence seizures. Inspired by experiments, we systematically study the crucial roles of two newly identified direct inhibitory striatal-cortical projections that project from the striatal D1 nucleus (SD1) and striatal D2 nucleus (SD2) to the cerebral cortex, in controlling absence seizures. Through computational simulation, we observe that typical 2–4 Hz spike and wave discharges (SWDs) can be induced through the pathological mechanism of cortical circuits, and both enhancing the inhibitory coupling weight on the striatal-cortical projections and improving the discharge activation level of striatal populations can effectively control typical SWDs. Furthermore, typical SWDs can be suppressed by appropriately adjusting several input projections directly related to the striatum, through regulating the activation level of striatal populations. Interestingly, several indirect striatum-related basal ganglia projections also have significant effects on the inhibition of typical SWDs, through the direct inhibitory striatal-cortical projections. Both the unidirectional control mode and bidirectional control mode for typical SWDs exist in our modified model. Importantly, the enhancement of coupling strengths on inhibitory striatal-cortical projections is beneficial for suppressing SWDs and may play a decisive regulatory role in the formation of control modes. Therefore, our study suggests that striatum may be potential effective targets for the treatment of absence seizures, through two newly identified direct inhibitory striatal-cortical projections. Interestingly, we find that external stimuli simultaneously targeting the striatum and another basal ganglia nucleus have a better control effect on SWDs than targeting a single basal ganglia nucleus, and the obtained results provide testable hypotheses for future experiments.
期刊介绍:
Cognitive Neurodynamics provides a unique forum of communication and cooperation for scientists and engineers working in the field of cognitive neurodynamics, intelligent science and applications, bridging the gap between theory and application, without any preference for pure theoretical, experimental or computational models.
The emphasis is to publish original models of cognitive neurodynamics, novel computational theories and experimental results. In particular, intelligent science inspired by cognitive neuroscience and neurodynamics is also very welcome.
The scope of Cognitive Neurodynamics covers cognitive neuroscience, neural computation based on dynamics, computer science, intelligent science as well as their interdisciplinary applications in the natural and engineering sciences. Papers that are appropriate for non-specialist readers are encouraged.
1. There is no page limit for manuscripts submitted to Cognitive Neurodynamics. Research papers should clearly represent an important advance of especially broad interest to researchers and technologists in neuroscience, biophysics, BCI, neural computer and intelligent robotics.
2. Cognitive Neurodynamics also welcomes brief communications: short papers reporting results that are of genuinely broad interest but that for one reason and another do not make a sufficiently complete story to justify a full article publication. Brief Communications should consist of approximately four manuscript pages.
3. Cognitive Neurodynamics publishes review articles in which a specific field is reviewed through an exhaustive literature survey. There are no restrictions on the number of pages. Review articles are usually invited, but submitted reviews will also be considered.