Ferroptosis as a molecular target of epigallocatechin gallate in diseases.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2024-09-12 DOI:10.1080/13813455.2024.2401892

Lili Wang,Chunlian Tang,Qizhi Zhang,Qun Pan

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Abstract

CONTEXT Ferroptosis is a novel form of cell death characterised by iron overload and lipid peroxidation. It is closely associated with many diseases, including cardiovascular diseases, tumours, and neurological diseases. The use of natural chemicals to modulate ferroptosis is of great concern because of the critical role ferroptosis plays in disease. The main active ingredient in green tea is epigallocatechin gallate (EGCG), which is the most abundant catechin in green tea. EGCG shows a wide range of biological and therapeutic effects in various diseases, including anti-inflammatory, antioxidant, anticancer, and cardioprotective. OBJECTIVE The purpose of this article is to summarise the existing information on the relationship between EGCG and ferroptosis. METHODS Articles related to EGCG and ferroptosis were searched in PubMed and Web of Science databases, and the literature was analysed. RESULTS AND CONCLUSION EGCG could improve ferroptosis-related diseases and affect the development of ferroptosis by regulating the nuclear factor erythroid 2-related factor 2, autophagy, microRNA, signal transducer and activator of transcription 1, and protein kinase D1 signalling pathways.

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表没食子儿茶素没食子酸酯在疾病中的分子靶点--铁突变。

CONTEXTFerroptosis 是一种新型的细胞死亡形式，其特点是铁超载和脂质过氧化。它与许多疾病密切相关，包括心血管疾病、肿瘤和神经系统疾病。由于铁突变在疾病中的关键作用，使用天然化学物质来调节铁突变引起了人们的极大关注。绿茶的主要活性成分是表没食子儿茶素没食子酸酯（EGCG），它是绿茶中含量最高的儿茶素。EGCG 在各种疾病中显示出广泛的生物和治疗作用，包括抗炎、抗氧化、抗癌和保护心脏。方法在 PubMed 和 Web of Science 数据库中搜索与 EGCG 和铁蛋白沉积有关的文章，并对文献进行分析。结果与结论EGCG可通过调节核因子红细胞2相关因子2、自噬、微RNA、转录信号转导子和激活子1以及蛋白激酶D1信号通路，改善铁变态反应相关疾病并影响铁变态反应的发展。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.