Role of CD86 on granulocyte in mediating the effect of Genus Roseburia on periodontitis

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Investigations Pub Date : 2024-09-12 DOI:10.1007/s00784-024-05915-9

Huihuang Ye, Xue Gao, Yike Ma, Shuai He, Zhihui Zhou

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Abstract

Objectives

This study aimed to explore the causal link between the gut microbiota and periodontitis, and to delineate and quantify the intermediary role of immune cells, so as to provide new insights into the pathogenesis, prevention and treatment of periodontitis.

Materials and methods

We employed a two-sample Mendelian randomization (MR) approach to analyze the genetic predictors of gut microbiota composition (covering 412 gut microbiota taxa and functions) and periodontitis (involving 4,784 cases and 272,252 controls) derived from genome-wide association study (GWAS) datasets. A subsequent two-step MR analysis was conducted to evaluate the extent to which immune cell traits (encompassing 731 immune cell characteristics) mediate the influence of gut microbiota on periodontitis risk.

Results

Our analysis implicated nine gut microbiota taxa as causal factors in periodontitis susceptibility (p < 0.05). Notably, the Genus Roseburia was identified as exerting a protective effect against periodontitis, partially mediated through the upregulation of CD86 expression on granulocytes, with an 8.15% mediation effect observed.

Conclusions

Our findings establish a causal relationship between the gut microbiota and periodontitis, highlighting the protective role of Roseburia against this condition. A notable proportion of this protective effect is mediated via the upregulation of CD86 on granulocytes.

Clinical relevance

It can provide new ideas for the pathogenesis, prevention and treatment for periodontitis through exploring the causal link between the gut microbiota and periodontitis, and describing and quantifying the intermediary role of immune cells.

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粒细胞上的 CD86 在调解蔷薇属植物对牙周炎的影响中的作用

目的本研究旨在探讨肠道微生物群与牙周炎之间的因果关系，并阐明和量化免疫细胞的中介作用，从而为牙周炎的发病机制、预防和治疗提供新的见解。材料与方法我们采用双样本孟德尔随机化（MR）方法分析了从全基因组关联研究（GWAS）数据集中获得的肠道微生物群组成（涵盖 412 个肠道微生物群分类群和功能）和牙周炎（涉及 4784 个病例和 272252 个对照）的遗传预测因子。随后进行了两步 MR 分析，以评估免疫细胞特征（包括 731 个免疫细胞特征）在多大程度上介导了肠道微生物群对牙周炎风险的影响。结论我们的研究结果确定了肠道微生物群与牙周炎之间的因果关系，突出了蔷薇属对牙周炎的保护作用。临床意义通过探索肠道微生物群与牙周炎之间的因果关系，并描述和量化免疫细胞的中介作用，可以为牙周炎的发病机制、预防和治疗提供新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.