Oxidative Stress in the Murine Model of Extraparenchymal Neurocysticercosis

IF 4.1 2区生物学 Q2 MICROBIOLOGY

Microorganisms Pub Date : 2024-09-08 DOI:10.3390/microorganisms12091860

Diego Generoso, Tatiane de Camargo Martins, Camila Renata Corrêa Camacho, Manuella Pacífico de Freitas Segredo, Sabrina Setembre Batah, Alexandre Todorovic Fabro, Edda Sciutto, Agnès Fleury, Pedro Tadao Hamamoto Filho, Marco Antônio Zanini

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Abstract

Oxidative stress is associated with several infectious diseases, as well as the severity of inflammatory reactions. The control of inflammation during parasite destruction is a target of neurocysticercosis treatment, as inflammation is strongly related to symptom severity. In this study, we investigated the presence of malondialdehyde and protein carbonyl, two by-products of reactive oxygen species (ROS), in an experimental model of extraparenchymal neurocysticercosis. Twenty male and twenty female rats were inoculated with 50 cysts of Taenia crassiceps in the subarachnoid space of the cisterna magna. Ten animals (five males and five females) were used as controls. Three months after inoculation, their brains were harvested for oxidative stress and histological assessments. Infected animals had higher scores for inflammatory cell infiltrates, malondialdehyde, and protein carbonyl. These results encourage future efforts to monitor oxidative stress status in neurocysticercosis, particularly in the context of controlling inflammation.

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小鼠脑膜外神经囊虫病模型中的氧化应激

氧化应激与多种传染病以及炎症反应的严重程度有关。在消灭寄生虫的过程中控制炎症是神经囊尾蚴病治疗的一个目标，因为炎症与症状的严重程度密切相关。在这项研究中，我们调查了在神经囊尾蚴病实验模型中存在的丙二醛和蛋白质羰基，它们是活性氧（ROS）的两种副产物。20 只雄性大鼠和 20 只雌性大鼠的蛛网膜下腔被接种了 50 个冠突温氏梭菌囊肿。十只动物（五公五母）作为对照组。接种三个月后，取其大脑进行氧化应激和组织学评估。受感染的动物在炎症细胞浸润、丙二醛和蛋白质羰基方面得分较高。这些结果鼓励人们今后努力监测神经囊虫病的氧化应激状态，尤其是在控制炎症的情况下。

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来源期刊

Microorganisms Medicine-Microbiology (medical)

CiteScore

7.40

自引率

6.70%

发文量

2168

审稿时长

20.03 days

期刊介绍： Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.

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