Association of Initial Muscle Fitness with Weight Loss and Metabolically Healthy Status in Children and Adolescents with Obesity: A Retrospective Study

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2024-08-24 DOI:10.3390/metabo14090468

Wenya Shang, Jiaqi Kong, Mengxue Zhang, Tao Chen, Linlin Zhao, Kun Wang, Qin Yang

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Abstract

This retrospective study aimed to investigate the association of initial muscular fitness (MF) with weight loss and metabolic health status in 282 children and adolescents with obesity during 3 to 4 weeks of diet- and exercise-based interventions. Metabolically healthy obesity (MHO) definitions established in 2023 and MF standards based on the 2021 Chinese children's grip strength grading were applied. The proportion of metabolically unhealthy obesity (MUO) was higher in the high MF group than in their low MF counterparts at baseline. After the intervention, neither group transitioned from MUO to MHO due to the high frequency of low HDL-C. High MF females showed a higher percentage of high systolic blood pressure (SBP) than low MF females before and after intervention. High MF males exhibited greater improvements in waist circumference, hip circumference, waist-hip ratio, triglycerides, total cholesterol, and LDL-C than low MF males. The benefits of weight loss and blood lipids obtained by males are more evident than those obtained by females under the same MF level. Thus, attention should be paid to females during weight loss regardless of MF levels. Precision therapy should prioritize the management of blood pressure and avoid excessive reduction in HDL-C levels to sustain metabolic health.

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儿童和青少年肥胖症患者的初始肌肉健美度与体重减轻和代谢健康状况的关系：回顾性研究

这项回顾性研究旨在调查282名肥胖儿童和青少年在3至4周的饮食和运动干预期间，初始肌肉健康状况（MF）与体重减轻和代谢健康状况的关系。采用了2023年制定的代谢健康肥胖（MHO）定义和基于2021年中国儿童握力分级的MF标准。基线时，高代谢健康肥胖组的代谢不健康肥胖（MUO）比例高于低代谢健康肥胖组。干预后，由于高密度脂蛋白胆固醇（HDL-C）较低，两组均未从 MUO 过渡到 MHO。在干预前后，高 MF 女性收缩压（SBP）偏高的比例均高于低 MF 女性。与低密度脂蛋白胆固醇男性相比，高密度脂蛋白胆固醇男性在腰围、臀围、腰臀比、甘油三酯、总胆固醇和低密度脂蛋白胆固醇方面的改善幅度更大。在相同的 MF 水平下，男性在减肥和血脂方面获得的益处比女性更明显。因此，无论 MF 水平如何，减肥期间都应关注女性。精准治疗应优先考虑控制血压，避免过度降低高密度脂蛋白胆固醇水平，以维持代谢健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.