Edaravone: A Possible Treatment for Acute Lung Injury

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2024-09-11 DOI:10.2147/ijgm.s467891

Ma Huang, Yalan Mo, Haiyun Lei, Miao Chen

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引用次数: 0

Abstract

Abstract: Despite technological advances in science and medicine, acute lung injury (ALI) is still associated with high mortality rates in the ICU. Therefore, finding novel drugs and treatment approaches is crucial to preventing ALI. Drug repurposing is a common practice in clinical research, primarily for drugs that have previously received approval for use in patients, to investigate novel uses of drugs and therapies. One such medication is edaravone, which is a highly effective free-radical scavenger that also has anti-inflammatory, anti-apoptotic, antioxidant, and anti-fibrotic effects. Both basic and clinical studies have shown that edaravone can treat different types of lung injury through its distinct properties. Edaravone exhibits significant protective benefits and holds promising clinical treatment potential for ALI caused by diverse factors, thereby offering a novel approach to treating ALI. This study aims to provide new insights and treatment options for ALI by reviewing both basic and clinical research on the use of edaravone. The focus is on evaluating the effectiveness of edaravone in treating ALI caused by various factors.

Keywords: acute lung injury, edaravone, oxidative stress, inflammation, apoptosis, fibrosis

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依达拉奉急性肺损伤的一种可能治疗方法

摘要：尽管科学和医学技术在不断进步，但急性肺损伤（ALI）在重症监护病房中的死亡率仍然很高。因此，寻找新型药物和治疗方法对预防 ALI 至关重要。药物再利用是临床研究中的一种常见做法，主要针对以前已获准用于患者的药物，以研究药物和疗法的新用途。依达拉奉就是这样一种药物，它是一种高效的自由基清除剂，同时还具有抗炎、抗细胞凋亡、抗氧化和抗纤维化的作用。基础和临床研究都表明，依达拉奉可以通过其独特的特性治疗不同类型的肺损伤。依达拉奉对由多种因素引起的 ALI 具有显著的保护作用和临床治疗潜力，从而为治疗 ALI 提供了一种新方法。本研究旨在通过回顾有关依达拉奉使用的基础和临床研究，为 ALI 提供新的见解和治疗方案。重点是评估依达拉奉治疗由各种因素引起的 ALI 的有效性。关键词：急性肺损伤、依达拉奉、氧化应激、炎症、细胞凋亡、纤维化

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.