Asymmetric Osteopenia in Adolescent Idiopathic Scoliosis Based on Hounsfield Unit of Computed Tomography

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2024-09-07 DOI:10.2147/ijgm.s478933

Chong Zhao, Shuaiqi Zhu, Yan Liang, Shuai Xu

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Abstract

Purpose: To characterize the asymmetrical loss of bone mass and identify the association between scoliosis and osteopenia in patients with adolescent idiopathic scoliosis (AIS).
Methods: Demographic information, Cobb angle, and Hounsfield unit (HU) of the neutral vertebra (NV) and apical vertebra (apex) of the major curve were collected retrospectively in 54 AIS patients. For 84 control subjects, HU values were measured at T12 and L5. Propensity score matching was performed to balance the interference of age and BMI.
Results: In the AIS group, the concave and convex lateral HU of the NV and the convex lateral HU of the apex were negatively correlated with the Cobb angle. The AIS patients had lower bilateral HU. The mean HU and the apex-convex HU were also lower in the AIS group, while the apex-concave HU was slightly higher. After matching, the apex-convex HU of the AIS group remained lower, while the apex-concave HU was higher.
Conclusion: Patients with AIS exhibit osteopenia, particularly on the convex side. The severity of scoliosis was found to be directly proportional to the severity of bone loss and the degree of bilateral osteopenia asymmetry. Appropriate intervention for bone loss may be able to curb the progression of scoliosis.

Keywords: adolescent idiopathic scoliosis, osteopenia, osteoporosis, Hounsfield unit, propensity score matching

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基于计算机断层扫描 Hounsfield 单位的青少年特发性脊柱侧弯症不对称骨质疏松症

目的：描述青少年特发性脊柱侧弯症（AIS）患者骨质非对称性流失的特征，并确定脊柱侧弯症与骨质疏松之间的关联：方法：回顾性收集了 54 名 AIS 患者的人口统计学信息、Cobb 角度以及中性椎体（NV）和大弯顶点椎体（顶点）的 Hounsfield 单位（HU）。对 84 名对照组受试者的 T12 和 L5 进行了 HU 值测量。为平衡年龄和体重指数的干扰，进行了倾向得分匹配：在 AIS 组中，NV 的凹侧和凸侧 HU 值以及顶点的凸侧 HU 值与 Cobb 角呈负相关。AIS 患者的双侧 HU 值较低。AIS 组的平均 HU 值和心尖凸 HU 值也较低，而心尖凹 HU 值稍高。匹配后，AIS 组的顶凸 HU 值仍然较低，而顶凹 HU 值较高：结论：AIS 患者表现出骨质疏松，尤其是凸侧骨质疏松。脊柱侧弯的严重程度与骨质流失的严重程度和双侧骨质疏松的不对称程度成正比。关键词：青少年特发性脊柱侧凸；骨质增生；骨质疏松症；Hounsfield单位；倾向得分匹配

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.