Salivary biomarkers in non-invasive oral cancer diagnostics: a comprehensive review.

IF 2.2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Applied Oral Science Pub Date : 2024-09-09 DOI:10.1590/1678-7757-2024-0151

Ravina Vats,Pooja Yadav,Afsareen Bano,Sapna Wadhwa,Rashmi Bhardwaj

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Abstract

OBJECTIVE This review aims to provide a comprehensive analysis of the effectiveness of saliva as a non-invasive diagnostic marker for oral cancer. Despite progress in oral cancer diagnosis and prognosis, the 5-year survival rate remains low due to the resistance to treatment and delayed diagnosis, which can be attributed to various factors including tobacco and alcohol consumption, genetic damage, and human papillomavirus (HPV). The potential use of saliva as an easily accessible non-invasive screening and diagnostic method arises from its direct contact with the lesion site. METHODOLOGY Data for this study were gathered via a comprehensive literature evaluation using search engines such as the PubMed, Web of Science, Google Scholar, and SciFinder. RESULTS Identifying salivary biomarkers shows potential to transform oral cancer diagnostics by offering a reliable alternative to the traditional invasive methods. Saliva is an abundant reservoir for both cell-bound and cell-free organic and inorganic constituents. Thus, saliva is an appropriate field for research in proteomics, genomics, metagenomics, and metabolomics. CONCLUSION This review provides a comprehensive elucidation of salivary biomarkers and their function in non-invasive oral cancer diagnosis, demonstrating their potential to enhance patient outcomes and reduce the impact of this devastating disease.

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非侵入性口腔癌诊断中的唾液生物标记物：全面综述。

目的：本综述旨在全面分析唾液作为口腔癌非侵入性诊断标志物的有效性。尽管在口腔癌的诊断和预后方面取得了进展，但由于治疗阻力和诊断延迟，5 年生存率仍然很低，而这些阻力和延迟可归因于各种因素，包括吸烟和饮酒、遗传损伤和人类乳头瘤病毒（HPV）。本研究的数据是通过使用 PubMed、Web of Science、Google Scholar 和 SciFinder 等搜索引擎对文献进行综合评估后收集的。结果发现唾液生物标志物为口腔癌诊断提供了可靠的替代方法，有望改变传统的侵入性方法。唾液中富含细胞结合的和不含细胞的有机和无机成分。因此，唾液是蛋白质组学、基因组学、元基因组学和代谢组学研究的合适领域。结论本综述全面阐明了唾液生物标志物及其在无创口腔癌诊断中的功能，展示了唾液生物标志物在提高患者预后和减少这种毁灭性疾病的影响方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Oral Science 医学-牙科与口腔外科

CiteScore

4.80

自引率

3.70%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal of Applied Oral Science is committed in publishing the scientific and technologic advances achieved by the dental community, according to the quality indicators and peer reviewed material, with the objective of assuring its acceptability at the local, regional, national and international levels. The primary goal of The Journal of Applied Oral Science is to publish the outcomes of original investigations as well as invited case reports and invited reviews in the field of Dentistry and related areas.