Tannic Acid-Loaded MgO and ZnO-Doped Antibacterial Hydroxyapatite for Orthopedic and Dental Applications

IF 2.1 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

JOM Pub Date : 2024-09-04 DOI:10.1007/s11837-024-06789-8

Claire Putelli, Joel Pilli, Gwenevere Gatto, Arjak Bhattacharjee

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Abstract

Hydroxyapatite (HA)-based materials are utilized as a bioactive ceramic for musculoskeletal reconstruction, owing to their chemical similarities to bone. However, they do not have any inherent antibacterial properties. Hence, post-surgical bacterial infection on HA scaffolds may cause osteomyelitis that needs to be rectified with costlier and more painful revision surgery. Our research aims to dope HA with transition metal oxides, such as ZnO and MgO, followed by loading tannic acid (TA) as an alternate antibacterial agent for various orthopedic and dental applications. The phase and microstructural investigation studies show no adverse effect as a result of doping. The combined effects of dopants and TA lead to ~ 98% antibacterial efficacy against S. aureus after 24 h of sample–bacterial interactions. The selected compositions do not show any adverse effects on the NIH3T3 cell line. In summary, our work proposes an alternate strategy to fabricate an antibacterial scaffold with TA-loaded ZnO and MgO-doped HA for various orthopedic and dental applications.

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用于骨科和牙科应用的单宁酸负载氧化镁和氧化锌掺杂抗菌羟基磷灰石

由于羟基磷灰石（HA）基材料与骨骼的化学性质相似，因此被用作肌肉骨骼重建的生物活性陶瓷。然而，它们并不具备任何固有的抗菌特性。因此，HA 支架上的术后细菌感染可能会导致骨髓炎，需要通过更昂贵、更痛苦的翻修手术来纠正。我们的研究旨在用过渡金属氧化物（如氧化锌和氧化镁）掺杂 HA，然后加入单宁酸（TA）作为替代抗菌剂，用于各种骨科和牙科应用。相位和微结构调查研究表明，掺杂不会产生不良影响。在样品与细菌相互作用 24 小时后，掺杂剂和 TA 的共同作用可使金黄色葡萄球菌的抗菌效力达到约 98%。所选成分对 NIH3T3 细胞系没有任何不良影响。总之，我们的工作提出了一种替代策略，即利用 TA 负载氧化锌和掺杂氧化镁的 HA 制备抗菌支架，用于各种骨科和牙科应用。

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来源期刊

JOM 工程技术-材料科学：综合

CiteScore

4.50

自引率

3.80%

发文量

540

审稿时长

2.8 months

期刊介绍： JOM is a technical journal devoted to exploring the many aspects of materials science and engineering. JOM reports scholarly work that explores the state-of-the-art processing, fabrication, design, and application of metals, ceramics, plastics, composites, and other materials. In pursuing this goal, JOM strives to balance the interests of the laboratory and the marketplace by reporting academic, industrial, and government-sponsored work from around the world.