Helicobacter pylori infection and associated risk factors among HIV-positive and HIV-negative individuals in Northern Ethiopia.

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2024-09-09 DOI:10.1016/j.jiac.2024.09.006

Tesfay Abadi,Takele Teklu,Tadelo Wondmagegn,Meseret Alem,Girmay Desalegn

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Abstract

BACKGROUND H. pylori infection is a common bacterial infection worldwide, but its prevalence varies widely between different regions and populations. The objective of this study was to determine the prevalence of H. pylori infection and associated risk factors among HIV-positive and HIV-negative individuals in northern Ethiopia. METHODS A cross-sectional study was conducted from June to September 2020 in four randomly selected health facilities located in the Tigray region of Ethiopia. A total of 463 study participants were enrolled, of whom 288 were HIV-positive and 175 were HIV-negative individuals. H. pylori stool antigen tests were performed to detect H. pylori infection. Additionally, CD4+ T cell counts were measured from only a certain number of participants. RESULTS The overall prevalence of H. pylori infection among enrolled study participants was 39.7%. Notably, the H. pylori infection rate was significantly higher in HIV-positive patients (43.4%) compared to HIV-negative individuals (33.7%); χ2 = 4.27, p = 0.039. Higher H. pylori prevalence was observed in participants with higher CD4+ T cell counts in both HIV-positive and HIV-negative individuals. Khat chewing habit, education, and monthly income levels were significantly associated with H. pylori infection in HIV-negative individuals, while the association between Body mass index (BMI) and H. pylori infection was observed in HIV-positive patients, but not HIV-negative individuals. CONCLUSION This study demonstrates a higher prevalence of H. pylori infection in HIV-positive patients compared to HIV-negative individuals, emphasizing the importance of comprehensive diagnostics, patient care, and management of H. pylori infection in HIV-positive individuals.

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埃塞俄比亚北部 HIV 阳性和 HIV 阴性人群中的幽门螺杆菌感染及相关风险因素。

背景幽门螺杆菌感染是全球常见的细菌感染，但不同地区和人群的感染率差异很大。本研究旨在确定埃塞俄比亚北部 HIV 阳性和 HIV 阴性人群中幽门螺杆菌感染率及相关风险因素。共招募了 463 名研究参与者，其中 288 人为 HIV 阳性者，175 人为 HIV 阴性者。幽门螺杆菌粪便抗原检测用于检测幽门螺杆菌感染。此外，仅对部分参与者的 CD4+ T 细胞计数进行了测量。结果参加研究的参与者中幽门螺杆菌感染的总流行率为 39.7%。值得注意的是，HIV 阳性患者的幽门螺杆菌感染率（43.4%）明显高于 HIV 阴性患者（33.7%）；χ2 = 4.27，P = 0.039。在 HIV 阳性和 HIV 阴性患者中，CD4+ T 细胞计数较高的参与者幽门螺杆菌感染率较高。咀嚼卡塔叶的习惯、教育程度和月收入水平与 HIV 阴性个体的幽门螺杆菌感染显著相关，而在 HIV 阳性患者中观察到身体质量指数（BMI）与幽门螺杆菌感染的相关性，但在 HIV 阴性个体中未观察到。

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.