Autophagy: the misty lands of Chlamydia trachomatis infection

IF 4.6 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2024-09-06 DOI:10.3389/fcimb.2024.1442995

Shan Zhang, Yufei Jiang, Yonghui Yu, Xuan Ouyang, Dongsheng Zhou, Yajun Song, Jun Jiao

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Abstract

Chlamydia are Gram-negative, obligate intracellular bacterial pathogens that infect eukaryotic cells and reside within a host-derived vacuole known as the inclusion. To facilitate intracellular replication, these bacteria must engage in host-pathogen interactions to obtain nutrients and membranes required for the growth of the inclusion, thereby sustaining prolonged bacterial colonization. Autophagy is a highly conserved process that delivers cytoplasmic substrates to the lysosome for degradation. Pathogens have developed strategies to manipulate and/or exploit autophagy to promote their replication and persistence. This review delineates recent advances in elucidating the interplay between Chlamydia trachomatis infection and autophagy in recent years, emphasizing the intricate strategies employed by both the Chlamydia pathogens and host cells. Gaining a deeper understanding of these interactions could unveil novel strategies for the prevention and treatment of Chlamydia infection.

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自噬：沙眼衣原体感染的迷雾之地

衣原体是革兰氏阴性的强制性细胞内细菌病原体，会感染真核细胞，并寄居在宿主产生的称为包涵体的空泡中。为了促进细胞内复制，这些细菌必须参与宿主与病原体之间的相互作用，以获得包涵体生长所需的营养物质和膜，从而维持长时间的细菌定植。自噬是一个高度保守的过程，可将细胞质底物运送到溶酶体进行降解。病原体已开发出操纵和/或利用自体吞噬的策略，以促进其复制和持续存在。这篇综述描述了近年来在阐明沙眼衣原体感染与自噬之间的相互作用方面取得的最新进展，强调了沙眼衣原体病原体和宿主细胞所采用的复杂策略。加深对这些相互作用的理解可以为预防和治疗衣原体感染提供新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.