Immunomodulatory hydrogels for tissue repair and regeneration

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

APL Materials Pub Date : 2024-08-23 DOI:10.1063/5.0228692

Xiangjun Liu, Yue Hu, Yikun Ju, Pu Yang, Naisi Shen, Anqi Yang, Rui Wu, Bairong Fang, Liangle Liu

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Abstract

Tissue repair and regeneration have long been a focus of research, with growing evidence highlighting the role played by immunomodulation. The repair of tissue cells can be significantly promoted through the localized immunomodulation of tissues. Hydrogels are increasingly used in this field due to their biocompatibility, versatility, and relative ease of fabrication. This Review highlights the critical role of inflammation and immune development in the complex process of tissue repair after injury, highlighting the dynamic interactions between immune cells that ultimately influence the outcome of tissue healing. We also summarize the precise functions of immune cells and their responses in various tissue injury scenarios, which are critical for harnessing the full potential of immunomodulatory strategies to promote tissue repair. We discuss recent advances in drug-carrying hydrogels, which offer promising avenues for tissue regeneration with precise control of the immune environment for constructive tissue repair. Further advances in our understanding of the mechanisms driving inflammation and immune cell behavior during tissue injury are expected to foster the development of increasingly effective hydrogel-based immunomodulatory strategies to promote tissue repair and regeneration.

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用于组织修复和再生的免疫调节水凝胶

组织修复和再生一直是研究的重点，越来越多的证据表明免疫调节发挥着重要作用。通过对组织进行局部免疫调节，可以大大促进组织细胞的修复。水凝胶因其生物相容性、多功能性和相对易于制造而越来越多地应用于这一领域。本综述强调了炎症和免疫发展在损伤后组织修复的复杂过程中的关键作用，突出了最终影响组织愈合结果的免疫细胞之间的动态相互作用。我们还总结了免疫细胞的精确功能及其在各种组织损伤情况下的反应，这对于充分发挥免疫调节策略的潜力以促进组织修复至关重要。我们讨论了载药水凝胶的最新进展，这种水凝胶为组织再生提供了前景广阔的途径，可精确控制免疫环境以实现建设性的组织修复。我们对组织损伤过程中炎症和免疫细胞行为的驱动机制的进一步了解有望促进基于水凝胶的免疫调节策略的发展，从而越来越有效地促进组织修复和再生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

APL Materials NANOSCIENCE & NANOTECHNOLOGYMATERIALS SCIE-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

9.60

自引率

3.30%

发文量

199

审稿时长

2 months

期刊介绍： APL Materials features original, experimental research on significant topical issues within the field of materials science. In order to highlight research at the forefront of materials science, emphasis is given to the quality and timeliness of the work. The journal considers theory or calculation when the work is particularly timely and relevant to applications. In addition to regular articles, the journal also publishes Special Topics, which report on cutting-edge areas in materials science, such as Perovskite Solar Cells, 2D Materials, and Beyond Lithium Ion Batteries.