Magnetic casein/CaCO3/Fe3O4 microspheres stimulate osteogenic differentiation

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

APL Materials Pub Date : 2024-09-03 DOI:10.1063/5.0229172

Mingjie Zhang, Xiaolei Li, Han Lin

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引用次数: 0

Abstract

The quality of life is significantly impacted by bone defects, which calls for the creation of optimum restorative materials with particular qualities. Current repair materials, such as metal alloys, polymer scaffolds, and bone cement, have a number of drawbacks, such as poor fracture toughness, non-degradability, and insufficient osteogenic ability. To address these challenges, we designed a novel magnetic casein/CaCO3/Fe3O4 microspheres (CCFM), combining biodegradability, osteoinductivity, osteoconductivity, and osteogenesis properties together. In vitro studies confirmed the outstanding biocompatibility and osteogenic differentiation effects on MC3T3-E1 cells of CCFM, highlighting their potential as a promising bone regeneration platform for clinical applications. As a novel bone repair material with superparamagnetic properties, CCFM not only possess good osteoinductivity, osteoconductivity, and osteogenesis properties but also can remain in the lesion location for a long time under an external magnetic field, representing a significant advancement in the field of bone tissue engineering and offering new possibilities for effective bone defect remediation and patient care.

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磁性酪蛋白/CaCO3/Fe3O4 微球刺激成骨分化

骨缺损严重影响着人们的生活质量，因此需要创造出具有特殊品质的最佳修复材料。目前的修复材料，如金属合金、聚合物支架和骨水泥，都存在许多缺点，如断裂韧性差、不可降解和成骨能力不足。为解决这些难题，我们设计了一种新型磁性酪蛋白/CaCO3/Fe3O4微球（CCFM），将生物可降解性、骨诱导性、骨传导性和成骨性能结合在一起。体外研究证实，CCFM 具有出色的生物相容性和对 MC3T3-E1 细胞的成骨分化作用，有望成为一种具有临床应用前景的骨再生平台。作为一种具有超顺磁性能的新型骨修复材料，CCFM 不仅具有良好的骨诱导性、骨传导性和成骨性，还能在外加磁场作用下长期存在于病变部位，是骨组织工程领域的一大进步，为有效修复骨缺损和患者护理提供了新的可能。

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来源期刊

APL Materials NANOSCIENCE & NANOTECHNOLOGYMATERIALS SCIE-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

9.60

自引率

3.30%

发文量

199

审稿时长

2 months

期刊介绍： APL Materials features original, experimental research on significant topical issues within the field of materials science. In order to highlight research at the forefront of materials science, emphasis is given to the quality and timeliness of the work. The journal considers theory or calculation when the work is particularly timely and relevant to applications. In addition to regular articles, the journal also publishes Special Topics, which report on cutting-edge areas in materials science, such as Perovskite Solar Cells, 2D Materials, and Beyond Lithium Ion Batteries.