BHLHE41, a transcriptional repressor involved in physiological processes and tumor development

IF 6.6 2区医学 Q1 Medicine

Cellular Oncology Pub Date : 2024-09-10 DOI:10.1007/s13402-024-00973-3

Caroline Bret, Fabienne Desmots-Loyer, Jérôme Moreaux, Thierry Fest

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Abstract

BHLHE41 is a nuclear transcriptional repressor that belongs to the basic helix-loop-helix protein superfamily. BHLHE41 expression tends to be restricted to specific tissues and is regulated by environmental cues and biological events. BHLHE41 homodimerizes or heterodimerizes with various partners, influencing its transcription factor function. BHLHE41 is involved in the regulation of many physiological processes implicated in tissue/organ homeostasis, such as myogenesis, adipogenesis, circadian rhythms and DNA repair. At cellular level, BHLHE41 is involved in the regulation of mesenchymal stem cell properties, tissue-specific macrophage functions and lymphoid lineage physiology. In several cancer types, BHLHE41 modulates the expression of different transcriptional programs influencing cell cycle control, apoptosis, invasiveness, epithelial to mesenchymal transition and hypoxia response in the tumor environment. Depending on the cancer cell type, BHLHE41 can act as a tumor suppressor or an oncogene, and could be a target for innovative therapies. This review summarizes the available knowledge on BHLHE41 structure, biological functions, regulation and potential partners, as well as its role in physiological processes, and its implication in major cancer steps.

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参与生理过程和肿瘤发生的转录抑制因子 BHLHE41

BHLHE41 是一种核转录抑制因子，属于碱性螺旋-环-螺旋蛋白超家族。BHLHE41 的表达往往局限于特定的组织，并受环境线索和生物事件的调控。BHLHE41 与各种伙伴同源或异源二聚体，从而影响其转录因子功能。BHLHE41 参与调控许多与组织/器官稳态有关的生理过程，如肌生成、脂肪生成、昼夜节律和 DNA 修复。在细胞水平上，BHLHE41 参与间充质干细胞特性、组织特异性巨噬细胞功能和淋巴细胞系生理学的调控。在几种癌症类型中，BHLHE41调节不同转录程序的表达，影响细胞周期控制、细胞凋亡、侵袭性、上皮到间质的转变以及肿瘤环境中的缺氧反应。根据癌细胞类型的不同，BHLHE41可作为肿瘤抑制因子或致癌基因，并可成为创新疗法的靶点。本综述总结了有关 BHLHE41 结构、生物功能、调控和潜在合作伙伴的现有知识，以及它在生理过程中的作用和在主要癌症步骤中的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

10.40

自引率

1.50%

发文量

审稿时长

16 weeks

期刊介绍： The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.