Candidaemia: A 9-Year Retrospective Analysis of Epidemiology and Antimicrobial Susceptibility in Tertiary Care Hospitals in Western China

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2024-09-05 DOI:10.2147/idr.s477815

Kun Li, Xue Yang, Long Li, Lan Zhi

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Abstract

Purpose: This investigation endeavors to scrutinize the resistance profiles to antifungal agents, alongside the clinical distribution of Candida isolates that yielded positive results in blood cultures at Suining Central Hospital spanning the years 2015 to 2023. The objective is to provide crucial epidemiological insights that may aid in early clinical intervention and judicious deployment of antifungal therapies.
Methods: This retrospective analysis analyses data on 182 different Candida strains with positive clinical blood cultures obtained from the Microbiology Laboratory of Suining Central Hospital over a period of nine consecutive years. The study involved identification of Candida species and assessment of resistance patterns to fungal drugs.
Results: Our analysis revealed that the median age of patients diagnosed with Candidaemia from the 182 strains was 62 years, with a distribution of 63.7% females and 36.3% males. Within the cohort of 182 Candida strains, Candida albicans constituted 32.4%, while non-albicans Candida species comprised 67.6% of the cases. Specifically, Candida tropicalis represented 37.4%, Candida glabrata 12.1%, Candida parapsilosis 11.0%,Candida guilliermondii 3.8%, and both Candida krusei and Candida Dublin accounted for 1.6% each. These Candida species were predominantly identified in intensive care units (ICU), hematology, gastroenterology, neurology centers, and endocrine metabolism units.
Conclusion: The findings of this investigation suggest a shift in the prevalence of non-Candida albicans species, notably C. tropicalis, as the predominant cause of Candidaemia at Suining Central Hospital, surpassing C. albicans. Although instances of antifungal resistance are infrequent, there has been a notable rise in resistance to azoles. This study provides important insights into the local epidemiology, which will be essential for informing the selection of empirical antifungal therapy and contributing to the global surveillance of antifungal resistance.

Keywords: candidemia, Candida species, antifungal agents, bloodstream

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念珠菌病：对中国西部地区三级医院流行病学和抗菌药物敏感性的 9 年回顾性分析

目的：本调查旨在研究遂宁市中心医院在2015年至2023年期间血液培养结果呈阳性的念珠菌分离株对抗真菌药物的耐药性以及临床分布情况。目的是提供重要的流行病学见解，以帮助早期临床干预和明智地使用抗真菌疗法：这项回顾性分析对连续九年从遂宁市中心医院微生物实验室获得的临床血液培养阳性的 182 株不同念珠菌进行了数据分析。研究包括鉴定念珠菌菌种和评估对真菌药物的耐药性模式：我们的分析表明，从 182 株菌株中确诊的念珠菌病患者的中位年龄为 62 岁，其中女性占 63.7%，男性占 36.3%。在 182 株念珠菌群中，白色念珠菌占 32.4%，非白色念珠菌占 67.6%。具体来说，热带念珠菌占 37.4%，光滑念珠菌占 12.1%，副丝状念珠菌占 11.0%，guilliermondii 念珠菌占 3.8%，克鲁塞念珠菌和都柏林念珠菌各占 1.6%。这些念珠菌主要出现在重症监护室（ICU）、血液科、消化科、神经病学中心和内分泌代谢科：调查结果表明，遂宁市中心医院白色念珠菌病的主要致病菌已从白色念珠菌转变为非白色念珠菌，特别是热带念珠菌。虽然抗真菌药物耐药性的情况并不常见，但对唑类药物的耐药性却明显增加。这项研究为了解当地的流行病学提供了重要依据，对选择经验性抗真菌治疗方法至关重要，并有助于全球对抗真菌耐药性的监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.