Whole-Genome Sequencing Identifies Functional Genes for Environmental Adaptation in Chinese Sheep.

IF 6.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Genetics and Genomics Pub Date : 2024-09-09 DOI:10.1016/j.jgg.2024.08.011

Yinan Niu,Yefang Li,Yuhetian Zhao,Xiaohong He,Qianjun Zhao,Yabin Pu,Yuehui Ma,Lin Jiang

{"title":"Whole-Genome Sequencing Identifies Functional Genes for Environmental Adaptation in Chinese Sheep.","authors":"Yinan Niu,Yefang Li,Yuhetian Zhao,Xiaohong He,Qianjun Zhao,Yabin Pu,Yuehui Ma,Lin Jiang","doi":"10.1016/j.jgg.2024.08.011","DOIUrl":null,"url":null,"abstract":"Sheep (Ovis aries), among the first domesticated species, are now globally widespread and exhibit remarkable adaptability to diverse environments. In this study, we perform whole-genome sequencing of 266 animals from 18 distinct Chinese sheep populations, each displaying unique phenotypes indicative of adaptation to varying environmental conditions. Integrating 131 environmental factors with single nucleotide polymorphism variations, we conduct a comprehensive genetic-environmental association analysis. This analysis identifies 35 key genes likely integral to the environmental adaptation of sheep. The functions of these genes include fat tail formation (HOXA10, HOXA11, JAZF1), wool characteristics (FER, FGF5, MITF, PDE4B), horn phenotypes (RXFP2), reproduction (HIBADH, TRIM71, C6H4orf22) and growth traits (ADGRL3, TRHDE). Notably, we observe a significant correlation between the frequency of missense mutations in the PAPSS2 and RXFP2 genes and variations in altitude. Our study reveals candidate genes for adaptive variation in sheep and demonstrates the diversity in the ways sheep adapt to their environment.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":null,"pages":null},"PeriodicalIF":6.6000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Genetics and Genomics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.jgg.2024.08.011","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Sheep (Ovis aries), among the first domesticated species, are now globally widespread and exhibit remarkable adaptability to diverse environments. In this study, we perform whole-genome sequencing of 266 animals from 18 distinct Chinese sheep populations, each displaying unique phenotypes indicative of adaptation to varying environmental conditions. Integrating 131 environmental factors with single nucleotide polymorphism variations, we conduct a comprehensive genetic-environmental association analysis. This analysis identifies 35 key genes likely integral to the environmental adaptation of sheep. The functions of these genes include fat tail formation (HOXA10, HOXA11, JAZF1), wool characteristics (FER, FGF5, MITF, PDE4B), horn phenotypes (RXFP2), reproduction (HIBADH, TRIM71, C6H4orf22) and growth traits (ADGRL3, TRHDE). Notably, we observe a significant correlation between the frequency of missense mutations in the PAPSS2 and RXFP2 genes and variations in altitude. Our study reveals candidate genes for adaptive variation in sheep and demonstrates the diversity in the ways sheep adapt to their environment.

查看原文本刊更多论文

全基因组测序发现中国绵羊适应环境的功能基因

绵羊（Ovis aries）是最早被驯化的物种之一，现已遍布全球，并表现出对不同环境的卓越适应能力。在这项研究中，我们对来自 18 个不同中国绵羊种群的 266 只绵羊进行了全基因组测序。将 131 种环境因素与单核苷酸多态性变异相结合，我们进行了全面的遗传环境关联分析。该分析确定了 35 个可能与绵羊的环境适应性密不可分的关键基因。这些基因的功能包括肥尾形成（HOXA10、HOXA11、JAZF1）、羊毛特征（FER、FGF5、MITF、PDE4B）、羊角表型（RXFP2）、繁殖（HIBADH、TRIM71、C6H4orf22）和生长性状（ADGRL3、TRHDE）。值得注意的是，我们观察到 PAPSS2 和 RXFP2 基因的错义突变频率与海拔变化之间存在显著的相关性。我们的研究揭示了绵羊适应性变异的候选基因，并展示了绵羊适应环境方式的多样性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Genetics and Genomics 生物-生化与分子生物学

CiteScore

8.20

自引率

3.40%

发文量

4756

审稿时长

14 days

期刊介绍： The Journal of Genetics and Genomics (JGG, formerly known as Acta Genetica Sinica ) is an international journal publishing peer-reviewed articles of novel and significant discoveries in the fields of genetics and genomics. Topics of particular interest include but are not limited to molecular genetics, developmental genetics, cytogenetics, epigenetics, medical genetics, population and evolutionary genetics, genomics and functional genomics as well as bioinformatics and computational biology.

文献相关原料

公司名称	产品信息	采购帮参考价格