Electrochemical determination of captopril using disposable graphite electrode modified with a molecularly imprinted film, accompanied by a ratiometric read-out

IF 2.7 3区 化学 Q2 CHEMISTRY, ANALYTICAL
Mohamed Mohamoud El-Wekil, Khalid Alhazzani, Al-Montaser Bellah H. Ali, Alanazi AZ, Hossieny Ibrahim, Mahmoud Darweesh
{"title":"Electrochemical determination of captopril using disposable graphite electrode modified with a molecularly imprinted film, accompanied by a ratiometric read-out","authors":"Mohamed Mohamoud El-Wekil, Khalid Alhazzani, Al-Montaser Bellah H. Ali, Alanazi AZ, Hossieny Ibrahim, Mahmoud Darweesh","doi":"10.1039/d4ay00724g","DOIUrl":null,"url":null,"abstract":"In this research paper, a novel \"signal on-off\" ratiometric-based electrochemical platform was developed for the sensitive and selective detection of captopril. Ratiometric responses were achieved by fabricating molecularly-imprinted polymers (MIPs) on the surface of a graphite electrode (GE) decorated with nitrogen (N) and sulfur (S) co-doped porous carbon and silver nanoparticles (Ag). The MIP layer was formed via electropolymerization of copper coordinated with pyrrole-3-carboxylic acid (functional monomer). Silver nanoparticles (Ag) were incorporated to enhance conductivity, surface area, and to serve as an internal reference output. Upon the addition of captopril, there was a decrease in the anodic oxidation current of Ag+ at around 0.067 V, coupled with an increase in the oxidation current at 0.54 V (Ag-captopril complex). Under optimized conditions, the electrochemical responses (IAg-captopril/IAg) increased linearly with increasing captopril concentration in the range of 1-450 nM, with a detection limit (S/N=3) of 0.3 nM. The ratiometric-based MIP electrochemical platform (Cu-MIP/NS-PC@Ag/GE) was successfully applied to detect captopril in complex matrices such as tablets, serum, and urine samples. This platform holds promise for sensitive and selective detection of captopril in various practical applications.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Methods","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ay00724g","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0

Abstract

In this research paper, a novel "signal on-off" ratiometric-based electrochemical platform was developed for the sensitive and selective detection of captopril. Ratiometric responses were achieved by fabricating molecularly-imprinted polymers (MIPs) on the surface of a graphite electrode (GE) decorated with nitrogen (N) and sulfur (S) co-doped porous carbon and silver nanoparticles (Ag). The MIP layer was formed via electropolymerization of copper coordinated with pyrrole-3-carboxylic acid (functional monomer). Silver nanoparticles (Ag) were incorporated to enhance conductivity, surface area, and to serve as an internal reference output. Upon the addition of captopril, there was a decrease in the anodic oxidation current of Ag+ at around 0.067 V, coupled with an increase in the oxidation current at 0.54 V (Ag-captopril complex). Under optimized conditions, the electrochemical responses (IAg-captopril/IAg) increased linearly with increasing captopril concentration in the range of 1-450 nM, with a detection limit (S/N=3) of 0.3 nM. The ratiometric-based MIP electrochemical platform (Cu-MIP/NS-PC@Ag/GE) was successfully applied to detect captopril in complex matrices such as tablets, serum, and urine samples. This platform holds promise for sensitive and selective detection of captopril in various practical applications.
使用分子印迹薄膜修饰的一次性石墨电极电化学测定卡托普利,并伴有比率读出器
本研究论文开发了一种新型的基于 "信号开关 "的比率测量电化学平台,用于卡托普利的灵敏度和选择性检测。通过在掺有氮(N)和硫(S)共掺多孔碳和纳米银颗粒(Ag)的石墨电极(GE)表面制造分子印迹聚合物(MIP),实现了比率反应。MIP 层是通过铜与吡咯-3-羧酸(功能单体)配位电聚合形成的。加入银纳米粒子(Ag)是为了增强导电性和表面积,并作为内部参考输出。加入卡托普利后,Ag+ 的阳极氧化电流在 0.067 V 左右下降,而氧化电流在 0.54 V 左右上升(Ag-卡托普利复合物)。在优化条件下,电化学反应(IAg-卡托普利/IAg)在 1-450 nM 范围内随卡托普利浓度的增加而线性增加,检测限(S/N=3)为 0.3 nM。基于比率计量的 MIP 电化学平台(Cu-MIP/NS-PC@Ag/GE)被成功应用于检测片剂、血清和尿液等复杂基质中的卡托普利。该平台有望在各种实际应用中灵敏、选择性地检测卡托普利。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Analytical Methods
Analytical Methods CHEMISTRY, ANALYTICAL-FOOD SCIENCE & TECHNOLOGY
CiteScore
5.10
自引率
3.20%
发文量
569
审稿时长
1.8 months
期刊介绍: Early applied demonstrations of new analytical methods with clear societal impact
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信