Biocompatibility and dimensional stability through the use of 3D‐printed scaffolds made by polycaprolactone and bioglass‐7: An in vitro and in vivo study
Ho‐Kyung Lim, In‐Seok Song, Won‐Cheul Choi, Young‐Jun Choi, Eun‐young Kim, Thi Hong Tham Phan, Ui‐Lyong Lee
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引用次数: 0
Abstract
PurposeThis experiment aimed to observe the differences in biological properties by producing BGS‐7 + PCL scaffolds with different weight fractions of BGS‐7 through 3D printing and to confirm whether using the scaffold for vertical bone augmentation is effective.Materials and MethodsCube‐shaped bioglass (BGS‐7) and polycaprolactone (PCL) scaffolds with different weight fractions (PCL alone, PCL with 15% and 30% BGS‐7) are produced using 3D printing. The surface hydroxyapatite (HA) apposition, the pH change, proliferation and attachment assays, and various gene expression levels are assessed. After a 7‐mm implant was inserted 3 mm into the rabbit calvaria, vertical bone augmentation is performed around the implant and inside the scaffold in four ways: scaffold only, scaffold+bone graft, bone graft only, and no graft. Sacrifice is performed at 6, 12, and 24 weeks, and the various parameters are compared radiographically and histologically.ResultsHA apposition, cell proliferation, cell attachment, and expression of osteogenic genes increase as the proportion of BGS‐7 increase. In the in vivo test, a higher bone–implant contact ratio, bone volume ratio, bone mineral density, and new bone area are observed when the scaffold and bone grafts were used together.ConclusionThe 3D‐printed scaffold, a mixture of BGS‐7 and PCL, exhibit higher biological compatibility as the proportion of BGS‐7 increase. Additionally, the use of scaffold is effective for vertical bone augmentation.
期刊介绍:
The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal.
The range of topics covered by the journals will include but be not limited to:
New scientific developments relating to bone
Implant surfaces and their relationship to the surrounding tissues
Computer aided implant designs
Computer aided prosthetic designs
Immediate implant loading
Immediate implant placement
Materials relating to bone induction and conduction
New surgical methods relating to implant placement
New materials and methods relating to implant restorations
Methods for determining implant stability
A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.