Molecular Genetic Markers of Neuroglia in Traumatic Brain Injury and Their Use for the Functional Assessment of Sportsmen

IF 0.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Evolutionary Biochemistry and Physiology Pub Date : 2024-08-29 DOI:10.1134/s0022093024040185

A. V. Cherepanova, Yu. R. Bravy, A. V. Karabelsky, M. M. Kotova, A. S. Shcherbakova, K. V. Apukhtin, V. S. Nikitin, M. Yu. Bobrov, A. V. Kalueff

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Abstract

Neuroglia performs multiple important physiological functions, including maintenance of brain homeostasis and metabolism, neuroprotection and modulation of neurotransmission. Studying the role of neuroglia is essential for understanding the pathogenesis of neurodegenerative diseases, as well as nervous tissue repair in inflammation or traumatic brain injuries, not infrequent in sports. However, it is difficult to analyze the processes occurring in neuroglial cells because of their high heterogeneity and no system of biomarkers allowing unambiguous assessment of the nervous system’s functional state as a whole. Here we analyze the data on clinically and biologically significant molecular genetic markers of different types of neuroglia and discuss the prospects for their use in sports physiology, including the functional assessment of athletes with TBI of varying severity and other types of sports-related traumas.

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创伤性脑损伤中神经胶质细胞的分子遗传标记及其在运动员功能评估中的应用

摘要神经胶质细胞具有多种重要的生理功能，包括维持大脑稳态和新陈代谢、神经保护和神经传递调节。研究神经胶质细胞的作用对于了解神经退行性疾病的发病机制以及炎症或创伤性脑损伤（在体育运动中并不少见）的神经组织修复至关重要。在这里，我们分析了不同类型神经胶质细胞具有临床和生物学意义的分子遗传标记的数据，并讨论了它们在运动生理学中的应用前景，包括对不同严重程度的创伤性脑损伤和其他类型的运动相关创伤的运动员进行功能评估。

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来源期刊

Journal of Evolutionary Biochemistry and Physiology 生物-进化生物学

自引率

33.30%

发文量

110

审稿时长

6-12 weeks

期刊介绍： Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.