K. V. Gordienko, N. A. Lukicheva, A. I. Akhmetzyanova, A. K. Kolupaev, O. A. Sachenkov, T. V. Baltina, E. R. Sadchikova, G. Yu. Vassilieva
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引用次数: 0
Abstract
The effect of gravitational unloading (antiorthostatic hindlimb
suspension) and subsequent recovery on the mineral density and mechanical
properties of the femoral and tibial bones in Wistar rats was studied
during oral administration of a human lactoferrin (LF) biotechnological
analog (200 mg/kg) derived from the milk of producer goats. Bone
mineral density was determined by dual energy X-ray absorptiometry,
while bone strength and stiffness were assessed via the three-point
bending test. It was shown that 21-day gravitational unloading led
to a decrease in the mineral density of the tibia and femur. Oral
LF administration had no significant effect on the mineral density
and projected area of the bones. There were no statistically significant
differences in mechanical stiffness between the experimental groups,
although after readaptation, the ultimate strength was significantly
higher in LF-administered groups. Thus, the results may indicate
the potential of LF preparations as prophylactic agents for maintaining
bone strength. At the same time, the maintaining of bone mineral
density under deficit-stimulating conditions requires a consideration
of alternative dosages and drug delivery methods.
期刊介绍:
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.