Biogenic Silver Oxide Nanoparticles for Enhanced Electrochemical (N-(4-Hydroxyphenyl)Acetamide) Sensing

Abstract

Nowadays, the identification of hepatotoxic compounds is necessary for clinical diagnosis as well as quantity management of their pharmaceutical formulations. In this study, silver oxide modified glassy carbon electrode synthesized using leaf extract of Ocimum tenuiflorum is adopted for sensing of (N-(4-hydroxyphenyl)acetamide). This drug molecules has regularly used pain killer that might cause liver injury under specific conditions. In addition, their physiochemical properties of bio-synthesized AgO nanoparticles have been examined with appropriate characterization techniques. Crystalline characteristic of AgO was non-destructively examined by the XRD-structural analysis. Structural examination claimed that the bioconstitutents of Ocimum tenuiflorum was effectively governs silver oxide formations from metal ions. The FT-IR vibrational assignments illustrate the AgO nanoparticles surface was influenced by some of the phytocompounds. Moreover, the overall particle’s uniformity and their distribution has been considerably controlled by the biomolecules. When oxidizing (N-(4-hydroxyphenyl)acetamide) in 0.1 M H₂SO₄, AgO NPs demonstrated superior electrocatalytic activity compared to bare SPE, and the separated oxidation peak potentials permitted simultaneous detection of the targets with broad linear ranges from 5 × 10^–6 to 3.4 × 10^–6 mol L^–1 low detection limit 8.5 × 10^–6 mol L^–1, and outstanding precision and accuracy (S/N = 3). The approach has been effectively used to identify ACOP in pharmaceutical pills because AgO nanoparticles demonstrate good stability, reproducibility, and repeatability.