Magnetic Nanodiscs That Destroy Glioblastoma Cells in a Targeted Way in an Alternating Nonheating Magnetic Field

IF 0.8 Q3 Engineering

Nanotechnologies in Russia Pub Date : 2024-09-10 DOI:10.1134/s2635167624600834

V. D. Fedotovskaya, S. S. Zamai, M. V. Zotova, A. N. Masyugin, F. V. Zelenov, N. A. Luzan, T. N. Zamai, A. A. Koshmanova, D. A. Kirichenko, E. D. Nikolaeva, O. S. Kolovskaya, I. A. Shchugoreva, G. S. Zamai, V. N. Zabluda, A. A. Borus, A. S. Bukatin, I. N. Lapin, V. A. Svetlichnyi, E. V. Morozov, K. A. Luk’yanenko, F. G. Zograf, F. N. Tomilin, A. E. Sokolov, A. A. Narodov, R. G. Galeev, A. S. Kichkailo

引用次数: 0

Abstract

The need to develop a surgical instrument that can most effectively and minimally invasively remove a malignant tumor, and distinguish and destroy only tumor cells without damaging the normal cells of healthy tissue surrounding the tumor is being considered. To achieve this goal, it is proposed to use nanodiscs with special magnetic, electronic and optical properties. Nanodiscs modified with recognition ligands (aptamers) are able to bind to tumor cells and destroy them under the influence of a weak, nonheating alternating magnetic field. This allows for effective tumor destruction while minimizing the impact on surrounding healthy tissue.

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在交变非加热磁场中以靶向方式摧毁胶质母细胞瘤细胞的磁性纳米盘

摘要目前正在考虑开发一种手术器械，它能最有效地微创切除恶性肿瘤，并且只区分和破坏肿瘤细胞，而不损伤肿瘤周围健康组织的正常细胞。为实现这一目标，建议使用具有特殊磁性、电子和光学特性的纳米盘。经过识别配体（aptamers）修饰的纳米光盘能够与肿瘤细胞结合，并在微弱、非加热交变磁场的影响下摧毁肿瘤细胞。这样既能有效摧毁肿瘤，又能最大限度地减少对周围健康组织的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.