Influence of Apamin on the Extracellularly Recorded Action Potentials Profiles of Subepicardial Cardiomyocytes of the Rat Heart in Myocardial Infarction
A. V. Stepanov, M. G. Dobretsov, Yu. A. Filippov, I. V. Kubasov
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引用次数: 0
Abstract
The role of small-conductance Ca2+-activated
K+-channels (SK channels) in the pathogenesis
of cardiomyopathies of various etiologies remains poorly understood.
The purpose of this work was to evaluate the effect of the blocker
of SK channels, apamin, on the extracellularly recorded action potentials
(eAPs) of subepicardial myocytes in the left ventricles of sham-operated
rats and rats with myocardial infarction caused by ischemia-reperfusion.
It was found that local delivery of the SK channel blocker apamin
at a concentration of 500 nM to the eAP recording area did not affect
the eAP profiles in the group of sham-operated rats but caused a
significant slowdown in the repolarization time and a decrease in
the afterhyperpolarization phase of eAPs in the group of rats with
myocardial infarction. These data suggest that changes in the waveform
of eAPs after infarction are associated with increased expression
and/or activity of SK channels in subepicardial myocytes. The possible
role of these channels in the structural and functional remodeling
of the myocardium of the left ventricle of the heart after ischemia-reperfusion
is discussed.
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