N. P. Komysheva, G. T. Shishkina, A. I. Mukhamadeeva, N. N. Dygalo
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引用次数: 0
Abstract
Peripheral cytokines may influence psychoemotional behavior,
but the role of interleukin-1beta (IL-1beta) in altering anxiety
and motor activity in response to inflammatory activation remains
unclear. To clarify this issue, correlations between behavioral
parameters in the elevated plus maze (EPM) test and plasma levels
of IL-1beta after administration of the proinflammatory stimulus
lipopolysaccharide (LPS) in different modes were analyzed in adult
male rats. LPS in doses of 0.5 or 5 mg/kg, as well as physiological
solution (control), were administered to rats intraperitoneally.
The most pronounced behavioral effect 24 hours after a single injection
was an endotoxin dose-dependent inhibition of the animals’ motor
activity. Twenty four hours after the 5 mg/kg, an increased anxiety
behavior was also observed. The behavioral changes caused by the
high dose of endotoxin were completely normalized after a week.
The behavior of the animals one day after the end of repeated injections
of LPS at a lower dose for a week (0.5 mg/kg; once every two days)
also did not differ from the control. The inhibition of motor activity
after LPS could be due to an increase in the level of IL-1beta in
the blood plasma, as indicated by the identified significant negative
correlations between IL-1beta and the corresponding behavioral parameters.
No significant correlation was found between the peripheral level
of IL-1beta and such a classic indicator of anxiety as the percentage
of entries into the open arms of the maze. In general, the obtained
results allow us to conclude that IL-1beta is an undoubted participant
in the mechanism of the transient inhibitory effect of LPS on motor
activity.
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