O. P. Shatova, I. M. Kolesnikova, E. M. Yagodkina, S. S. Kaydoshko, A. M. Gaponov, S. A. Roumiantsev, A. V. Shestopalov
{"title":"Tryptophan Signaling Molecules in Children with Different Developmental Dynamics of Obesity","authors":"O. P. Shatova, I. M. Kolesnikova, E. M. Yagodkina, S. S. Kaydoshko, A. M. Gaponov, S. A. Roumiantsev, A. V. Shestopalov","doi":"10.1134/s002209302404001x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The high incidence of childhood obesity is a big healthcare\nchallenge worldwide, which is fraught with the development of not\nonly numerous somatic comorbidities but also children’s social maladaptation. Searching\nfor early biochemical markers of obesity stabilization and its progression\nat an older age is very important for identifying risk groups and\npreventing the development of obesity and its complications. Our\nstudy showed that the child’ sex, which is often disregarded in\nthese situations, should necessarily be considered when assessing\nthe developmental dynamics of obesity. Whereas in girls, a decrease\nin serum serotonin concentrations may serve as a marker of obesity\nstabilization/progression, in boys, this tendency can be predicted\nby reduced serum indole-3-acrylate levels. In both sexes, elevated\nfecal indole-3-carboxaldehyde levels can be indicative of obesity\nstabilization/progression.</p>","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s002209302404001x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The high incidence of childhood obesity is a big healthcare
challenge worldwide, which is fraught with the development of not
only numerous somatic comorbidities but also children’s social maladaptation. Searching
for early biochemical markers of obesity stabilization and its progression
at an older age is very important for identifying risk groups and
preventing the development of obesity and its complications. Our
study showed that the child’ sex, which is often disregarded in
these situations, should necessarily be considered when assessing
the developmental dynamics of obesity. Whereas in girls, a decrease
in serum serotonin concentrations may serve as a marker of obesity
stabilization/progression, in boys, this tendency can be predicted
by reduced serum indole-3-acrylate levels. In both sexes, elevated
fecal indole-3-carboxaldehyde levels can be indicative of obesity
stabilization/progression.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
