Alagu Sankareswaran, Pooja Kunte, Diane P Fraser, Mobeen Shaik, Michael N Weedon, Richard A Oram, Chittaranjan S Yajnik, Giriraj R Chandak
{"title":"Type 1 Diabetes Genetic Risk Score classifies diabetes subtypes in Indians: Impact of HLA diversity on the lower discriminative ability","authors":"Alagu Sankareswaran, Pooja Kunte, Diane P Fraser, Mobeen Shaik, Michael N Weedon, Richard A Oram, Chittaranjan S Yajnik, Giriraj R Chandak","doi":"10.1101/2024.08.31.24312873","DOIUrl":null,"url":null,"abstract":"<strong>Objectives</strong> Genetic Risk scores (GRS) classify diabetes types, type 1 (T1D) and type 2 (T2D) in Europeans but the power is limited in other ancestries. We explored the performance of T1DGRS and potential reasons for inferior discrimination ability in diabetes-type classification in Indians.","PeriodicalId":501375,"journal":{"name":"medRxiv - Genetic and Genomic Medicine","volume":"131 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Genetic and Genomic Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.31.24312873","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives Genetic Risk scores (GRS) classify diabetes types, type 1 (T1D) and type 2 (T2D) in Europeans but the power is limited in other ancestries. We explored the performance of T1DGRS and potential reasons for inferior discrimination ability in diabetes-type classification in Indians.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
